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Iodine trapping and organification in patients with chronic renal failure

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Abstract

In vitro thyroid function tests were studied in 30 patients on regular hemodialysis. In addition, 8 patients (one not yet dialyzed) underwent perchlorate discharge testing and the salivary to plasma ratio of131I was measured to identify defects in iodine uptake or organification. When compared with 35 healthy controls, uremic patients had lower total T4 (5.8±0.4 vs 8.6±0.3 μg/100 ml) and total T3 (81±6 vs 124±5 ng/100 ml) but T3RU was higher in dialysis patients (35.5±0.9 vs 28±0.5%,P<0.01). The TSH levels were not different from those of controls. The RAI uptake 1 h after perchlorate was significantly higher than the control valve (0.6±0.14 vs 0.06±0.04,P<0.05). Similarly, the salivary to plasma ratio of131I was higher in patients with chronic renal failure (70±10:1 vs 40±4:1). It is concluded that there is altered iodine trapping in CRF patients but iodine organification appears to be normal.

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References

  • Chopra IJ, Chopra U, Smith SR, Reza M, Solomon DH (1975) Reciprocal changes in serum concentration of 3,3′,5′-triiodothyronine (reverse T3) and 3,3′,5-triiodothyronine (T3) in systemic illnesses. J Clin Endocrinol Metab 41:1043–1049

    Google Scholar 

  • Cole CH (1973) Decreased oubain sensitive adenosine triphosphatase activity in the erythrocyte membrane of patients with chronic renal disease. Clin Sci Mol Med 45:775–784

    Google Scholar 

  • Cuttelod S, LeMarchand-Beraud T, Magnenat P, Perret C, Poli S, Vannoti A (1974) Effect of age and role of kidneys and liver on thyrotropin turnover in man. Metabolism 23:101–113

    Google Scholar 

  • Czernichow P, Dauzet MC, Broyer M, Rappaport R (1976) Abnormal TSH, PRL, and GH response to TSH releasing factor in chronic renal failure. J Clin Endocrinol Metab 43:630–637

    Google Scholar 

  • Dandona P, Newton D, Platts MM (1977) Long-term hemodialysis and thyroid function. Br Med J 1:134–136

    Google Scholar 

  • Hershman JM, Jones CM, Bailey AL (1972) Reciprocal changes in serum thyrotropin and free thyroxine produced by heparin. J Clin Endocrinol Metab 34:574–579

    Google Scholar 

  • Hershman JM, Krugman LG, Kopple JD, Reed AW, Azukizawa M, Shinaberger JH (1978) Thyroid function in patients undergoing maintenance haemodialysis: Unexplained low serum thyroxine concentration. Metabolism 27:755–759

    Google Scholar 

  • Jaosoo A, Murray IPC, Parkin J, Robertson MR, Jeremy D (1974) Abnormalities of in-vitro thyroid function tests in renal disease. Q J Med 43:245–261

    Google Scholar 

  • Kalk WJ, Morley JE, Gold CH, Meyers A (1980) Thyroid function tests in patients on regular hemodialysis. Nephron 25:173–178

    Google Scholar 

  • Kramer HJ, Gospodinov D, Kruck F (1972) Inhibition of transport ATPase by uraemic toxins. Proc Europ Dialy Transplant Assoc (Ed. Cameron JG) Pitman, London, p 521–532

    Google Scholar 

  • Kramer HJ, Backer A, Kruck F (1974) Inhibition of intestinal (Na+K+)-ATPase in experimental uremia. Clin Chim Acta 50:13–18

    Google Scholar 

  • Lim VS, Fang VS, Katz AI, Refetoff S (1977) Thyroid dysfunction in chronic renal failure. J Clin Invest 60:522–534

    Google Scholar 

  • Minkoff L, Gaertner G, Darab M, Mercier C, Levin ML (1972) Inhibition of brain sodium potassium ATPase in uremic rats. J Lab Clin Med 80:71–78

    Google Scholar 

  • Neuhaus C, Baumann G, Walser A, Tholen H (1975) Serum thyroxine and thyroid-binding proteins in chronic renal failure without nephrosis. J Clin Endocrinol Metab 41:395–398

    Google Scholar 

  • Oddie TH, Flanigan WJ, Fisher DA (1970) Iodine and thyroxine metabolism in anephric patients receiving chronic peritoneal dialysis. J Clin Endocrinol Metab 31:277–282

    Google Scholar 

  • Ramirez G, Jubiz W, Gutch CF, Bloomer HA, Siegler R, Kolff WJ (1973) Thyroid abnormalities in renal failure. Ann Intern Med 79:500–504

    Google Scholar 

  • Ramirez G, O'Neil W Jr, Jubiz W, Bloomer HA (1976) Thyroid dysfunction in uremia: evidence for thyroid and hypophyseal abnormalities. Ann Intern Med 84:672–676

    Google Scholar 

  • Silverberg OS, Ulan RA, Fawcett DM, Dorsetov JB, Grace M, Baltcher K (1973) Effects of chronic haemodialysis on thyroid function in chronic renal failure. Can Med Assoc J 109:282–286

    Google Scholar 

  • Spector DA, Davis PJ, Helderman JH, Bell B, Utiger RD (1976) Thyroid function and metabolic state in chronic renal failure. Ann Intern Med 85:724–730

    Google Scholar 

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Authors and Affiliations

  1. The Neuroendocrine Research Laboratory, Minneapolis VA Medical Center, Minneapolis, Minnesota, USA

    Arshag D. Mooradian, John E. Morley, William K. Korchik, David Ma & Rex B. Shafer

  2. Department of Nuclear Medicine, Minneapolis VA Medical Center, Minneapolis, Minnesota, USA

    Arshag D. Mooradian, John E. Morley, William K. Korchik, David Ma & Rex B. Shafer

  3. Department of Nephrology, Minneapolis VA Medical Center, Minneapolis, Minnesota, USA

    Arshag D. Mooradian, John E. Morley, William K. Korchik, David Ma & Rex B. Shafer

  4. Department of Endocrinology, Minneapolis VA Medical Center, Minneapolis, Minnesota, USA

    Arshag D. Mooradian, John E. Morley, William K. Korchik, David Ma & Rex B. Shafer

  5. Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA

    Arshag D. Mooradian, John E. Morley, William K. Korchik, David Ma & Rex B. Shafer

  6. Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA

    Arshag D. Mooradian, John E. Morley, William K. Korchik, David Ma & Rex B. Shafer

Authors
  1. Arshag D. Mooradian
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  2. John E. Morley
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  3. William K. Korchik
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  4. David Ma
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  5. Rex B. Shafer
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Additional information

This research was supported by the NIH Training Grant AMO 7203

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Mooradian, A.D., Morley, J.E., Korchik, W.K. et al. Iodine trapping and organification in patients with chronic renal failure. Eur J Nucl Med 8, 495–498 (1983). https://doi.org/10.1007/BF00598909

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  • DOI: https://doi.org/10.1007/BF00598909

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