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Assessment of skeletal uptake of99mTc-diphosphonate over a five day period

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Abstract

A new method for the sequential monitoring of skeletal uptake of99mTc-diphosphonate over a 5-day period, utilising both a gamma camera and whole-body monitor, is presented. It has been found that diphosphonate continues to be removed from bone over this period. Normal subjects appear to lose skeletal activity initially at a more rapid rate than those with altered skeletal metabolism and it is suggested that differences in binding characteristics may exist.

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References

  • Citrin DL, Bessent RG, Greig WR (1977) A comparison of the sensitivity and accuracy of the 99m-Tc-phosphate bone scan and skeletal radiography in the diagnosis of bone metastases. Clin Radiol 28:107–117

    Google Scholar 

  • Fogelman I, Bessent RG, Turner JG, Citrin DL, Boyle IT, Greig WR (1978) The use of whole-body retention of Tc-99m diphosphonate in the diagnosis of metabolic bone disease. J Nucl Med 19:270–275

    Google Scholar 

  • Fogelman I, Bessent RG (1982) Age-related alterations in skeletal metabolism—24-hour whole-body retention of diphosphonate studies in 250 normal subjects: concise communication. J Nucl Med 23:296–300

    Google Scholar 

  • Francis MD (1969) The inhibition of calcium hydroxyapatite crystal growth by polyphosphonates and polyphosphates. Calcif Tissue Int 3:151–162

    Google Scholar 

  • Jones AG, Francis MD, Davis MA (1976) Bone scanning: radionuclide reaction mechanisms. Semin Nucl Med 6:3–18

    Google Scholar 

  • McDougall JR, Citrin DL (1975) Bone scanning: The current position. Scott Med J 20:149–151

    Google Scholar 

  • Martin W, Fogelman I, Bessent RG (1981) Measurement of 24-hour whole-body retention of Tc-99m HEDP by a gamma camera. J Nucl Med 22:542–545

    Google Scholar 

  • Smith ML, Martin W, Fogelman I, Bessent RG (1982) Relative distribution of diphosphonate between bone and soft tissue at 4 and 24 hours: concise communication. J Nucl Med 24:208–211

    Google Scholar 

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Fogelman, I., Martin, W. Assessment of skeletal uptake of99mTc-diphosphonate over a five day period. Eur J Nucl Med 8, 489–490 (1983). https://doi.org/10.1007/BF00598907

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  • DOI: https://doi.org/10.1007/BF00598907

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