Chemistry of Natural Compounds

, Volume 25, Issue 6, pp 698–704 | Cite as

Analysis and prediction of primary structures of proteins using a computer

  • L. Ya. Yukel'son
  • I. I. Parilis
  • G. L. Bussel'
  • D. Kh. Khamidov


On the basis of a computer analysis of four classes of toxic polypeptides, generalized primary structures of each class have been obtained which can be used for planning the synthesis of biologically active compounds.


Amino Acid Composition Primary Structure USSR Academy Scorpion Venom Trans Influence 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature cited

  1. 1.
    R. F. Doolittle, Science,214, 149 (1981).CrossRefGoogle Scholar
  2. 2.
    G. G. Kneale and M. J. Bishop, Comput. Appl. Biosci.,1, No. 1, 11 (1985).PubMedGoogle Scholar
  3. 3.
    V. A. Ratner and N. A. Kolchanov, The Role of Data Banks and Complexes of Research Programs in the Development of the Theory of Molecular-Genetic Control Systems [in Russian], Proceedings of the ITsiG SO AN SSSR [Institute of Cytology and Genetics, Siberian Division of the USSR Academy of Sciences], Novosibirsk (1983), p. 42.Google Scholar
  4. 4.
    A. A. Aleksandrov, Zh. Vses. Khim. Obshch. im. D. I. Mendeleeva,29, No. 2, 64 (1984).Google Scholar
  5. 5.
    Yu. A. Pankov, Vestn. Akad. Med. Nauk. SSSR,2, 9 (1983).Google Scholar
  6. 6.
    M. O. Dayhoff, Atlas of Protein Sequence and Structure, National Biomedical Research Foundation, Washington, DC., Vol. 5 (1972) Suppl. 1 (1973); Suppl. 2 (1976); Suppl. 3 (1979).Google Scholar
  7. 7.
    W. M. Fitch and E. Margoliash, Science,155, 279 (1967).CrossRefGoogle Scholar
  8. 8.
    F. Dzh. Aiala, Zh. Obshch. Biol.,17, No. 4, 479 (1986).Google Scholar
  9. 9.
    Yu. P. Adler, E. V. Markova, and Yu. V. Granovskii, The Planning of Experiments in the Search for Optimum Conditions [in Russian], Nauka, Moscow (1976), p. 279.Google Scholar
  10. 10.
    V. N. Vapnik, Algorithms and Programs for the Restoration of Relationships [in Russian], Nauka, Moscow (1984), p. 816.Google Scholar
  11. 11.
    A. J. Stuper, W. E. Brugger, and P. C. Jurs, Computer Assisted Studies of Biological Activity Relations and Biological Function, Wiley, New York (1978). [Russian translation, Mir, Moscow (1982), p. 235].Google Scholar
  12. 12.
    V. E. Golender and A. B. Rozenblit, Computer Methods of Constructing Drugs [in Russian], Zinatne, Riga (1987), p. 238.Google Scholar
  13. 13.
    D. J. Strydom, Snake Venoms (Volumes 52 of Handbook of Experimental Pharmacology), Springer, New York (1979), No. 4, p. 258.Google Scholar
  14. 14.
    M. J. Dufton and R. C. Hider, CRC Crit. Rev. Biochem.,14, No. 2, 113 (1983).CrossRefGoogle Scholar
  15. 15.
    I. I. Parilis, G. L. Bussel', L. Ya. Yukel'son, and D. Kh. Khamidov, Dokl. Akad. Nauk UzSSR, No. 10, 47 (1984).Google Scholar
  16. 16.
    G. I. Chipens, Vestn. Akad. Med. Nauk SSSR,2, 18 (1983).Google Scholar
  17. 17.
    I. I. Parilis, G. L. Bussel', L. Ya. Yukel'son, and D. Kh. Khamidov, Mol. Biol. (Moscow),22, No. 6, 1697 (1988).Google Scholar
  18. 18.
    G. L. Bussel', I. I. Parilis, L. Ya. Yukel'son, and D. Kh. Khamidov, in: Abstracts of Lectures of the VIth All-Union Symposium on Molecular Mechanism of Genetic Processes [in Russian], Moscow (1987), p. 65.Google Scholar
  19. 19.
    M. J. Dufton, A. F. Drake, and H. Rochat, Biochim. Biphys. Acta,869, No. 1, 16 (1986).CrossRefGoogle Scholar
  20. 20.
    W. C. Barker and M. O. Dayhoff, in: Proceedings of the 7th Annual Symposium of Computing Applied to Medical Care, Washington, Silver Springs, MD (1983), p. 584.Google Scholar
  21. 21.
    G. I. Chipens, L. K. Polevaya, N. I. Veretennikova, and A. Yu. Krikis, The Structure and Functions of Small Peptides [in Russian], Zinatne, Riga (1980), p. 328.Google Scholar

Copyright information

© Plenum Publishing Corporation 1990

Authors and Affiliations

  • L. Ya. Yukel'son
  • I. I. Parilis
  • G. L. Bussel'
  • D. Kh. Khamidov

There are no affiliations available

Personalised recommendations