Withasteroids of Physalis. IX. Physangulide — The first natural 22S-withasteroid

  • O. E. Vasina
  • N. D. Abdullaev
  • N. K. Abubakirov


A new withasteroid — physangulide — has been isolated from the leaves ofPhysalis angulata L. It has been shown that physangulide is the first natural 22S-withanolide. Its structure has been determined as 3β,4β,20,24,25-pentahydroxy-1-oxo-5β,6β-epoxy-20R,22S,24S,25R-withanolide. Its1H and13C NMR spectra, confirming this interpretation, are given.


Lactone Chiral Center Keto Group Cotton Effect Amorphous Yellow Powder 

Literature cited

  1. 1.
    E. Glotter, M. Sahai, and I. Kirson, J. Chem. Soc., Perkin I, 2241 (1985).Google Scholar
  2. 2.
    I. Kirson and E. Glotter, J. Nat. Prod.,44, No. 6, 633 (1981).CrossRefGoogle Scholar
  3. 3.
    K. L. Dhar and M. L. Raina, Phytochemistry,12, No. 12, 476 (1973).CrossRefGoogle Scholar
  4. 4.
    A. K. Kalla, M. L. Raina, K. L. Dhar, M. A. Qurishi, and G. Snatzke, Phytochemistry,18, No. 4, 637 (1979).CrossRefGoogle Scholar
  5. 5.
    O. E. Vasina, V. A. Maslennikova, N. D. Abdullaev, and N. K. Abibakirov, in: VIIIth Indo-Soviet Symposium on the Chemistry of Natural Products, 8–12 December, 1986, Hyderabad (India), Abstracts (Supplement), p. 33.Google Scholar
  6. 6.
    I. Kirson, D. Lavie, S. M. Albonico, and H. R. Juliani, Tetrahedron,26, No. 21, 5063 (1970).CrossRefGoogle Scholar
  7. 7.
    S. W. Pelletier, G. Gebeychu, J. Nowacki, and N. V. Mody, Heterocycles,15, No. 1, 317 (1981).CrossRefGoogle Scholar
  8. 8.
    A. V. Kamernitskii, I. G. Reshetova, and V. A. Krivoruchko, Khim. Prir. Soedin., No. 2, 156 (1977).Google Scholar
  9. 9.
    O. E. Vasina, V. A. Maslennikova, N. D. Abdullaev, and N. K. Abubakirov, Khim. Prir. Soedin., No. 5, 596 (1986).Google Scholar
  10. 10.
    N. D. Abdullaev, O. E. Vasina, V. A. Maslennikova, and N. K. Abubakirov, Khim. Prir. Soedin, No. 3, 326 (1986).Google Scholar
  11. 11.
    D. Lavie, Bol. Inst. Quim. Univ. Nacl. Auton. Max.,22, 181 (1970).Google Scholar
  12. 12.
    G. P. Moiseeva, O. E. Vasina, and N. K. Abubakirov, Khim. Prir. Soedin., 371 (1990) [following paper in this issue].Google Scholar

Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • O. E. Vasina
  • N. D. Abdullaev
  • N. K. Abubakirov

There are no affiliations available

Personalised recommendations