Use of the silylation reaction in synthesis of fragment 1–4 of the ACTH sequence
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A new effective method of synthesizing fragment 1–4 of the ACTH sequence ensuring a high overall yield of the desired product is proposed. This result is achieved thanks to the wide use of the silylation reaction in the synthesis, which has permitted a considerable simplification of the process and the avoidance of the formation of by-products. The peptides synthesized have been characterized by their angles of optical rotation, chromatographic mobilities, and melting points. A table of chemical shifts in the13C NMR spectra of the final and intermediate compounds is given.
KeywordsPeptide Organic Chemistry Melting Point Chemical Shift Optical Rotation
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