Chemistry of Natural Compounds

, Volume 24, Issue 2, pp 211–215 | Cite as

Use of the silylation reaction in synthesis of fragment 1–4 of the ACTH sequence

  • A. K. Rabinovich
  • E. P. Krysin


A new effective method of synthesizing fragment 1–4 of the ACTH sequence ensuring a high overall yield of the desired product is proposed. This result is achieved thanks to the wide use of the silylation reaction in the synthesis, which has permitted a considerable simplification of the process and the avoidance of the formation of by-products. The peptides synthesized have been characterized by their angles of optical rotation, chromatographic mobilities, and melting points. A table of chemical shifts in the13C NMR spectra of the final and intermediate compounds is given.


Peptide Organic Chemistry Melting Point Chemical Shift Optical Rotation 
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Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • A. K. Rabinovich
  • E. P. Krysin

There are no affiliations available

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