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Elektrophoretische Untersuchungen der Glucose-6-phosphatdehydrogenase in Erythrocyten von Psoriatikern

Electrophoretical determinations of glucose-6-phosphate-dehydrogenase in erythrocytes of psoriatic patients

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Summary

Red cell haemolysates from 103 psoriasis patients and 100 control persons were electrophoretically examined for G-6-PDH isoenzymes. In both groups, with the exception of one person with psoriasis, all people were found to have a single band, probably type B, the commonest type found in all populations. One psoriatic patient was found to possess an electrophoretically faster band with a normal enzyme activity however, of which the exact identification has not been possible up to now.

It is hypothesized that G-6-PDH deficiency and psoriasis are mutually exclusive. In regions with high frequency of G-6-PDH deficiency, no psoriasis or only at low frequencies will be found. Since G-6-PDH deficiency is found in high frequencies in areas with endemic malaria, it is to be expected that malaria and psoriasis will also have a negative relationship.

Zusammenfassung

Bei 103 manifesten Psoriatikern und 100 Kontrollpersonen ohne eigene oder familiär bekannte Psoriasisbelastung wurde die Erythrocyten-G-6-PDH elektrophoretisch bestimmt. In beiden Gruppen wiesen alle Personen mit einer Ausnahme bei den Psoriatikern eine einzige Bande auf, die dem Typ B entsprach, der im allgemeinen in jeder Population der häufigste ist. Bei einem Psoriatiker konnte eine Variante schnellerer elektrophoretischer Wanderungsgeschwindigkeit jedoch mit normaler Enzymaktivität festgestellt werden, deren genaue Identifizierung bis jetzt noch nicht möglich war.

Es wird angenommen, daß G-6-PDH-Mangel und Psoriasis sich gegenseitig weitgehend ausschließen bzw. Regionen mit hohem Vorkommen von G-6-PDH-Mangel-Varianten nur sehr selten oder überhaupt keine Psoriasis aufweisen. Weiterhin wird aus der Tatsache, daß in Gegenden mit hoher G-6-PDH-Mangel-Frequenz auch endemisch Malaria gesteigert vorkommt, der Schluß gezogen, daß sich das Vorkommen von Malaria und Psoriasis in ein und demselben Gebiet gegenseitig weitgehend ausschließen.

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Authors and Affiliations

  1. Hautklinik und Anthropologisches Institut, Johannes Gutenberg-Universität Mainz, BRD

    H. Holzmann, R. Ananthakrishnan, Lia Eckes, B. Morsches, H. Walter & N. Hoede

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  1. H. Holzmann
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  2. R. Ananthakrishnan
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  3. Lia Eckes
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  4. B. Morsches
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  5. H. Walter
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  6. N. Hoede
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Additional information

Die Untersuchungen wurden durch Mittel der Landesversicherungsanstalt Speyer ermöglicht.

Alexander von Humboldt Fellow.

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Holzmann, H., Ananthakrishnan, R., Eckes, L. et al. Elektrophoretische Untersuchungen der Glucose-6-phosphatdehydrogenase in Erythrocyten von Psoriatikern. Arch. Derm. Forsch. 247, 283–288 (1973). https://doi.org/10.1007/BF00596248

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  • DOI: https://doi.org/10.1007/BF00596248

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