Archiv für dermatologische Forschung

, Volume 247, Issue 2, pp 99–109 | Cite as

Ultrastructure of signet ring cells in cutaneous metastases of gastric carcinoma

  • Akihiko Sato
  • Okitaka Maie
  • Taizo Kato


Electron microscopic observations were performed on signet ring cells in cutaneous metastases of two patients with gastric carcinoma.

The signet ring cells seen in these cases differed markedly. By comparing similarities in their features to normal gastric cellular constituents, they were classified as one of two types; the pyloric gland cell type or the goblet cell type.

In general, pyloric gland-type signet ring cells are found in the mucous secreting carcinoma that has invaded the mucosa of the pyloric region, whereas the goblettype signet ring cells are observed in almost all mucous secreting gastric carcinomas with intestinalization of gastric mucosa.

In both cases, the primary sites of carcinoma could be correctly predicted by electron microscopic and histochemical studies of the signet ring cells in the cutaneous metastases.


Gastric Mucosa Gastric Carcinoma Goblet Cell Gland Cell Electron Microscopic Observation 


Elektronenmikroskopische Untersuchungen der Siegelringzellen in den Hautmetastasen von zwei Fällen mit Magencarcinomen führten zu folgenden Ergebnissen:

Die Siegelringzellen waren voneinander ganz verschieden und konnten durch Vergleich der Form mit den Epithelzellen der normalen Magenschleimhaut in zwei Typen klassifiziert werden: Pylorusdrüsen-Typ und Becherzellen-Typ.

Im allgemeinen wird angenommen, daß die Siegelringzelle vom Pylorusdrüsen-Typ aus den in der Pylorusschleimhaut infiltrierenden Carcinomen stammt, während die Siegelringzelle vom Becherzellen-Typ aus Carcinomen der Magenschleimhaut mit Intestinalisation stammt.

In zwei Fällen, konnte der Sitz der Primärcarcinome nach elektronenmikroskopischer und histochemischer Untersuchung der Siegelringzellen in den Hautmetastasen richtig vorhergesagt werden.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Barka, T., Anderson, P. J.: Histochemical methods for acid phosphatase using hexazonium pararosaniline as coupler. J. Histochem. Cytochem.10, 741–753 (1962).Google Scholar
  2. Behnke, O., Zelander, T.: Preservation of intercellular substances by the cationic dye alcian blue in preparative procedures for electron microscopy. J. Ultrastruct. Res.31, 424–438 (1970).Google Scholar
  3. Graumann, W.: Pylorusdrüsen. Handbuch der Histochemie, Bd. II/2, S. 321–322. Stuttgart: G. Fischer 1964a.Google Scholar
  4. Graumann, W.: Becherzellen. Handbuch der Histochemie, Bd. II/2, S. 329–332. Stuttgart: G. Fischer 1964b.Google Scholar
  5. Rambourg, A., Leblond, C. P.: Electron microscope observations on the carbohydrate-rich cell coat present at the surface of cells in the rat. J. Cell Biol.32, 27–53 (1967a).Google Scholar
  6. Rambourg, A., Leblond, C. P.: Staining of basement membranes and associated structures by the Periodic Acid-Schiff and Periodic Acid-Silver Methenamine techniques. J. Ultrastruct. Res.20, 306–309 (1967b).Google Scholar
  7. Sasano, N., Nakamura, K., Arai, M., Akazaki, K.: Ultrastructural cell patterns in human gastric carcinoma compared with non-neoplasmic gastric mucosa—Histogenetic analysis of carcinoma by mucin histochemistry. J. nat. Cancer Inst.43, 783–802 (1969).Google Scholar
  8. Suzuki, T., Sekiyama, S.: Application of methenamine silver stain for electron microscopy. J. Electron Micro (Japan).10, 36–38 (1961).Google Scholar

Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • Akihiko Sato
    • 1
  • Okitaka Maie
    • 1
  • Taizo Kato
    • 1
  1. 1.Department of DermatologySchool of Medicine Tohoku UniversitySendaiJapan

Personalised recommendations