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Archiv für dermatologische Forschung

, Volume 247, Issue 2, pp 99–109 | Cite as

Ultrastructure of signet ring cells in cutaneous metastases of gastric carcinoma

  • Akihiko Sato
  • Okitaka Maie
  • Taizo Kato
Article

Summary

Electron microscopic observations were performed on signet ring cells in cutaneous metastases of two patients with gastric carcinoma.

The signet ring cells seen in these cases differed markedly. By comparing similarities in their features to normal gastric cellular constituents, they were classified as one of two types; the pyloric gland cell type or the goblet cell type.

In general, pyloric gland-type signet ring cells are found in the mucous secreting carcinoma that has invaded the mucosa of the pyloric region, whereas the goblettype signet ring cells are observed in almost all mucous secreting gastric carcinomas with intestinalization of gastric mucosa.

In both cases, the primary sites of carcinoma could be correctly predicted by electron microscopic and histochemical studies of the signet ring cells in the cutaneous metastases.

Keywords

Gastric Mucosa Gastric Carcinoma Goblet Cell Gland Cell Electron Microscopic Observation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Zusammenfassung

Elektronenmikroskopische Untersuchungen der Siegelringzellen in den Hautmetastasen von zwei Fällen mit Magencarcinomen führten zu folgenden Ergebnissen:

Die Siegelringzellen waren voneinander ganz verschieden und konnten durch Vergleich der Form mit den Epithelzellen der normalen Magenschleimhaut in zwei Typen klassifiziert werden: Pylorusdrüsen-Typ und Becherzellen-Typ.

Im allgemeinen wird angenommen, daß die Siegelringzelle vom Pylorusdrüsen-Typ aus den in der Pylorusschleimhaut infiltrierenden Carcinomen stammt, während die Siegelringzelle vom Becherzellen-Typ aus Carcinomen der Magenschleimhaut mit Intestinalisation stammt.

In zwei Fällen, konnte der Sitz der Primärcarcinome nach elektronenmikroskopischer und histochemischer Untersuchung der Siegelringzellen in den Hautmetastasen richtig vorhergesagt werden.

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References

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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • Akihiko Sato
    • 1
  • Okitaka Maie
    • 1
  • Taizo Kato
    • 1
  1. 1.Department of DermatologySchool of Medicine Tohoku UniversitySendaiJapan

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