European Journal of Pediatrics

, Volume 148, Issue 5, pp 401–402 | Cite as

Treatment of fever and neutropenia with antibiotics versus antibiotics plus intravenous gammaglobulin in childhood leukemia

  • T. Sumer
  • A. Abumelha
  • I. Al-Mulhim
  • M. Al-Fadil


Thirty-three children with leukemia who had neutropenia and fever were randomized to receive cefataxim and amikacin, versus the same antibiotics plus intravenous gammaglobulin (i.v. IgG). Duration of neutropenia, hospitalization and the interruption of chemotherapy were not different in the two groups; however, duration of fever was significantly shorter in the i.v. IgG group.

Key words

Gammaglobulin Leukemia Neutropenia 



acute lymphoblastic leukemia


acute non-lymphocytic leukemia


complete blood counts

i.v. IgG

intravenous gammaglobulin


  1. 1.
    Alexander WJ, Deitcher H, Kornhuber B, Luiken GA, Ochs HD, Pirofsky B (1979) Which is factual basis in theory and clinical practice for the use of intravenous gammaglobulin in the treatment of severe bacterial infections? Vox Sang 37:116–128Google Scholar
  2. 2.
    Ax W, Kanzy EJ, Seiler FR (1981) In-vivo phagocytosis:enhancement of bacterial clearence by native and enzyme treated immunoglobulins. Immunobiology 159:349–365Google Scholar
  3. 3.
    Bussel JB, Cunningham-Rundles C (1985) Intravenous use of gammaglobulin: humoral immunodeficiency, immune thrombocytopenic purpura and newer indications. Cancer Invest 3:361–366Google Scholar
  4. 4.
    Cunningham-Rundles C, Siegal FP, Smithwick EM (1984) Efficacy of intravenous immunoglobulin in primary humoral immunodeficiency disease. Ann Intern Med 101:435–439Google Scholar
  5. 5.
    Ikeda S, Ichimaru M (1985) The use of SM-4300 against the severe infections complicated with hematological diseases. Jpn J Antibiot 38:2559–2563Google Scholar
  6. 6.
    Jacobs RF, Kiel DP, Sanders ML, Steel RW (1985) Phagocytosis of type III groups B streptococci by neonatal monocytes: enhancement by fibrocetin and gammaglobulin. J Infect Dis 152:695–700Google Scholar
  7. 7.
    Kornhuber B (1979) Administration of intravenous immunoglobulin to children with malignant diseases. In: Alving BM, Finlaysen JS (eds) Immunoglobulins; characteristics and uses of intravenous preparations. US Department of Health and Human Services, Bethesda, Md., pp 107–109Google Scholar
  8. 8.
    McClelland OBL, Yap PL (1984) Clinical use of immunoglobulins. Clin Haematol 13:39–74Google Scholar
  9. 9.
    Nagamatsu I, Sato Y, Miyanoshita A (1985) Clinical studies on SM-4300 in children. Jpn J Antibiot 38:2565–2570Google Scholar
  10. 10.
    Pirofsky B, Montanaro A (1984) Prolonged interval high-dose intravenous immunoglobulin in patients with primary immunodeficiency states. Am J Med 76:67–72Google Scholar
  11. 11.
    Polmar HS, Sorenson RU (1984) Efficacy and safety of high dose intravenous immune globulin therapy for antibody deficient syndromes. Am J Med 76:8Google Scholar
  12. 12.
    Suzuki N, Watanabe A (1985) Clinical evaluation on combination therapy antibiotics and gamma globulin preparation (SM-4300) in the field of pediatrics. Jpn J Antibiot 38:1571–1576Google Scholar
  13. 13.
    Takashima T, Tabuki K, Nishimura T, Tagaki M (1985) Laboratory and clinical studies on SM-4300 in pediatric field. Jpn J Antibiot 38: 2594–2602Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • T. Sumer
    • 1
  • A. Abumelha
    • 2
  • I. Al-Mulhim
    • 2
  • M. Al-Fadil
    • 2
  1. 1.Department of PediatricsRobert Wood Johnson University HospitalNew BrunswickUSA
  2. 2.Department of PediatricsKing Faisal UniversityDammamSaudi Arabia

Personalised recommendations