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Acute myelogenous leukaemia in children

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Abstract

Acute myelogeneous leukaemia in childhood is considerably more resistant to chemotherapy than the acute lymphocytic leukaemias. Recently, more aggressive therapy has improved the outlook for children with this difficult form of leukaemia. Long-term disease-free survival of children achieving remission has been reported to be more than 40% in some studies. This paper reviews both the present concept of leukaemogenesis as well as some of the more recent therapeutic studies on childhood AML.

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Abbreviations

ALL:

acute lymphocytic leukaemia

AML:

acute myelogenous leukaemia

Ara-C:

cytosine arabinoside

BMT:

bone marrow transplantation

CFU:

colony forming unit

CSF:

colony stimulating factor

G:

granulocyte

M:

macrophage

MDS:

myelodysplastic syndrome

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  1. Department of Paediatric Research, Rikshospitalet, N-0027, Oslo 1, Norway

    S. O. Lie

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Lie, S.O. Acute myelogenous leukaemia in children. Eur J Pediatr 148, 382–388 (1989). https://doi.org/10.1007/BF00595892

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