Summary
A cytosol testosterone binding protein is found in the bald and hairy zones of male pattern alopecia. Simple kinetic differences between both regions towards testosterone binding indicate structural differences and greater affinity of the binding protein in bald regions towards testosterone and its steroid competitors. These differences may be linked to the pathogenic cause of baldness.
Zusammenfassung
Ein testosteronbindendes Protein wurde in den haarlosen und behaarten Hautarealen der männlichen Glatze gefunden. Die unterschiedliche Kinetik der Testosteronbindung in beiden Hautarealen weist sowohl auf strukturelle Unterschiede, als auch auf eine größere Affinität des testosteronbindenden Proteins zum Testosteron und seinen Steroidanalogen in haarlosen Bezirken hin. Diese unterschiedliche Bindungsaktivität spielt möglicherweise bei der Glatzenbildung eine pathogenetische Rolle.
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Bassas, E., Pinto, B. Experimental study on the male pattern alopecia. Arch. Derm. Forsch. 248, 339–346 (1974). https://doi.org/10.1007/BF00595552
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DOI: https://doi.org/10.1007/BF00595552