Summary
Proflavine inhibits in vitro and in vivo the incorporation of precursors of nucleic acids and proteins in the hamster melanoma A Mel 3. This effect is particularly evident for tumour mitochondria and seems to be a specific phenomenon.
Zusammenfassung
Proflavin hemmt in vitro und in vivo den Einbau von Nucleinsäure- und Proteinvorstufen in Zellkernen und Mitochondrien des Hamstermelanoms A Mel 3. Diese Hemmung ist bei Tumormitochondrien besonders deutlich und sehr wahrscheinlich ein spezifisches Phänomen.
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Literatur
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Balda, B.R., Birkmayer, G.D. Zur Hemmwirkung von Proflavin auf den Einbau von DNS-, RNS- und Proteinvorstufen im Hamstermelanom. Arch. Derm. Forsch. 243, 107–113 (1972). https://doi.org/10.1007/BF00595223
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DOI: https://doi.org/10.1007/BF00595223