Abstract
Combined use of magnetoencephalography (MEG), functional magnetic resonance imaging (f-MRI), and motor evoked potentials (MEPs) was carried out on one patient in an attempt to localise precisely a structural lesion to the central sulcus. A small cyst in the right frontoparietal region was thought to be the cause of generalised seizures in an otherwise asymptomatic woman. First the primary sensory cortex was identified with magnetic source imaging (MSI) of somatosensory evoked magnetic fields using MEG and MRI. Second, the motor area of the hand was identified using f-MRI during handsqueezing. Then transcranial magnetic stimulation localised the hand motor area on the scalp, which was mapped onto the MRI. There was a good agreement between MSI, f-MRI and MEP as to the location of the sensorimotor cortex and its relationship to the lesion. Multimodality mapping techniques may thus prove useful in the precise localisation of cortical lesions, and in the preoperative determination of the best treatment for peri-rolandic lesions.
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Brenner D, Lipton J, Kaufman L, Williamson SJ (1978) Somatically evoked magnetic fields of the human brain. Science 199: 81–83
Okada, YC, Tannenbaum R, Williamson SJ, Kaufman L (1984) Somatotopic organization of the human somatosensory cortex revealed by neuromagnetic measurements. Exp Brain Res 56: 197–205
Orrison WW, Davis LE, Sullivan GW, Mettler FA Jr, Flynn ER (1990) Anatomical localization of cerebral cortical function by magnetoencephalography combined with MR imaging and CT. AJNR 11: 713–716
Suk J, Ribary U, Cappell J, Yamamoto T, Llinás R (1991) Anatomical localization revealed by MEG recording of the human somatosensory system. Electro-encephalogr Clin Neurophysiol 78: 185–196
Sutherling WW, Crandal PH, Darcey TM, Becker DP, Levesque MF, Barth DS (1988) The magnetic and electrical fields agree with intracranial localizations of somatosensory cortex. Neurology 38: 1705–1714
Wood CC, Cohen D, Cuffin BN, Yarita M, Allison T (1985) Electrical sources in the human somatosensory cortex: identification by combined magnetic and electrical potential recording. Science 227: 1051–1053
Benzel EC, Lewine JD, Bucholz RD, Orrison WW Jr (1993) Magnetic source imaging: a review of theMagnes system of biomagnetic technologies incorporated. Neurosurgery 33: 252–259
Gallen CC, Sobel DF, Waltz T, Aung M, Copeland B, Schwartz BJ, Hirschkoff EC, Bloom FE (1993) Noninvasive presurgical neuromagnetic mapping of somatosensory cortex. Neurosurgery 33: 260–268
Kamada K, Takeuchi F, Kuriki S, Oshiro O, Houkin K, Abe H (1993) Functional neurosurgical simulation with brain surface magnetic resonance images and magnetoencephalography. Neurosurgery 33: 269–273
Morioka T, Yamamoto T, Katsuta T, Fujii K, Fukui M (1994) Presurgical 3-dimensional magnetic source imaging of the somatosensory cortex in a patient with a peri-Rolandic lesion. Neurosurgery 34: 930–934
Orrison WW Jr, Rose DF, Hart BL, Maclin EL, Sanders JA, Willis BK, Marchand EP, Wood CC, Davis LE (1992) Noninvasive preoperative cortical localization by magnetic source imaging. AJNR 13: 1124–1128
Sobel DF, Gallen CC, Schwartz BJ, Waltz TA, Copeland B, Yamada S, Hirschkoff EC, Bloom FE (1993) Locating the central sulcus: comparison of MR anatomic and magnetoencephalographic functional methods. AJNR 14: 915–925
Williamson SJ, Kaufman L (1981) Biomagnetism. J Magnetism Magn Mater 22: 129–202
Yamada S, Gallen CC (1993) Biomagnetic technologies: magnetic source imaging (MSI). Magnes Biomagnetometer. Neurosurgery 33: 166–168
Cohen LG, Hallett M (1988) Methodology for noninvasive mapping of human motor cortex with electrical stimulation. Electroencephalogr Clin Neurophysiol 69: 403–411
Roland PE, Meyer E, Shibasaki T, Yamamoto YL, Thompson CJ (1982) Regional cerebral blood flow changes in cortex and basal ganglia during voluntary movements in normal volunteers. J Neurophysiol 48: 467–480
Bandettini PA, Wong EC, Hinks PS, Tikofsky RS, Hyde JS (1992) Time course EPI of human brain function during task activation. Magn Reson Med 25: 390–397
Belliveau JW, Kennedy DN, McKinstry RC, Buchbinder BR, Weisskoff RM, Cohen MS, Vevea JM, Brady TJ, Rosen BR (1991) Functional mapping of the human visual cortex by magnetic resonance imaging. Science 254: 716–719
Belliveau JW, Kwong KK, Kennedy DN, Baker JR, Stern CE, Benson R, Chesler DA, Weisskoff RM, Cohen MS, Tootell RBH, Fox PT, Brady TJ, Rosen BR (1992) Magnetic resonance imaging mapping of brain function. Human visual cortex. Invest Radiol 27: S59-S65
Kim S-G, Ashe J, Georgopoulos AP, Merkle H, Ellermann JM, Menon RS, Ogawa S, Ugurbil K (1993) Functional imaging of human motor cortex at high magnetic field. J Neurophysiol 69: 297–302
Kwong KK, Belliveau JW, Chesler DA, Goldberg IE, Weisskoff RM, Poncelet BP, Kennedy DN, Hoppel BE, Cohen MS, Turner R, Cheng H-M, Brady TJ, Rosen BR (1992) Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci USA 89: 5675–5679
Ogawa S, Lee T-M (1990) Magnetic resonance imaging of blood vessels at high fields: in vivo and vitro measurements and image simulation. Magn Reson Med 16: 9–18
Ogawa S, Lee T-M, Kay AR, Tank DW (1990) Brain magnetic resonance imaging with contrast dependent blood oxygenation. Proc Natl Acad Sci USA 87: 9868–9872
Ogawa S, Lee T-M, Nayak AS, Glynn P (1990) Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med 14: 68–78
Ogawa S, Tank DW, Menon R, Elllermann JM, Kim S-G, Merkle H, Ugurbil K (1992) Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci USA 89: 5951–5955
Amassian VE, Cracco RQ, Maccabee PJ (1989) Focal stimulation of human cerebral cortex with the magnetic coil: a comparison with electrical stimulation. Electroencephalogr Clin Neurophysiol 74: 401–416
Barker AT, Jalinous R, Freeston IL (1985) Non-invasive magnetic stimulation of the human motor cortex. Lancet I: 1106–1107
Brasil-Neto JP, McShane LM, Fuhr P, Hallett M, Cohen LG (1992) Topographic mapping of the human motor cortex with magnetic stimulation: factors affecting accuracy and reproducibility. Electroencephalogr Clin Neurophysiol 85: 9–16
Cohen LG, Roth BJ, Wassermann EM, Topka H, Fuhr P, Schultz J, Hallett M (1991) Magnetic stimulation of the human cerebral cortex, an indicator of reorganization in motor pathways in certain pathological conditions. J Clin Neurophysiol 8: 56–65
Meyer B-U, Britton TC, Kloten H, Steinmetz H, Benecke R (1991) Coil placement in magnetic brain stimulation related to skull and brain anatomy. Electroencephalogr Clin Neurophysiol 81: 38–46
Mills KR, Boniface SJ, Schubert M (1992) Magnetic brain stimulation with a double coil: the importance of coil orientation. Electroencephalogr Clin Neurophysiol 85: 17–21
Ueno S, Matsuda T, Fujiki M (1990) Functional mapping of the human motor cortex obtained by focal and vectorial magnetic stimulation of the brain. IEEE Trans Magn 26: 1539–1544
Wassermann EM, McShane LM, Hallett M, Cohen LG (1992) Noninvasive mapping of muscle representations in human motor cortex. Electroencephalogr Clin Neurophysiol 85: 1–8
Wilson SA, Thickbroom GW, Mastaglia FL (1993) Transcranial magnetic stimulation mapping of the motor cortex in normal subjects. The representation of two intrinsic hand muscles. J Neurosci 118: 134–144
Yamamoto T, Williamson SJ, Kaufman L, Nicholson C, Llinás R (1988) Magnetic localization of neural activity in the human brain. Proc Natl Acad Sci USA 85: 8732–8736
Turner R, Le Bihan D, Moonen CTW, Despres D, Frank J (1991) Echo-planar time course MRI of cat brain oxygenation changes. Magn Reson Med 22: 159–166
Thulborn KR, Waterton JC, Matthews PM, Radda GK (1982) Dependence of the transverse relaxation time of water protons in whole blood at high field. Biochim Biophys Acta 714: 265–270
Fox PT, Raichle ME (1986) Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci USA 83: 1140–1144
Fox PT, Raichle ME, Mintun MA, Dence C (1988) Nonoxidative glucose consumption during focal physiologic neural activity. Science 241: 462–464
Penfield W, Boldrey E (1937) Somatic motor and sensory representation in the cerebral cortex of man as studied by electrical stimulation. Brain 60: 389–443
Uematsu S, Lesser R, Fisher RS, Gordon B, Hara K, Krauss GL, Vining EP, Webber RW (1992) Motor and sensory cortex in humans: topography studies with chronic subdural stimulation. Neurosurgery 31: 59–72
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Morioka, T., Mizushima, A., Yamamoto, T. et al. Functional mapping of the sensorimotor cortex: combined use of magnetoencephalography, functional MRI, and motor evoked potentials. Neuroradiology 37, 526–530 (1995). https://doi.org/10.1007/BF00593709
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DOI: https://doi.org/10.1007/BF00593709