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Zur Morphologie der Dünndarmschleimhaut bei Morbus Whipple (intestinale Lipodystrophie)

Whipple's disease: Light and electron microscopic observations on serial intestinal biopsies in two cases

Eine licht- und elektronenoptische Untersuchung

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Summary

Light- and electron microscopic observations on intestinal biopsies of two cases of Whipple's disease, before and after antibiotic treatment, are described. Special attention is given to the bacteria as known since 1961 in connection with this disease, their etiologic role and problems of their chemical wall structure, and the ensuing tissue reaction. Comparisons between the morphology of the intestine and the clinical symptoms before and during antibiotic therapy give further evidence of the importance of the mucosal epithelium for the intestinal fat reabsorption.

Zusammenfassung

Es werden licht- und elektronenoptische Befunde an Dünndarmbiopsien bei zwei Fällen von Morbus Whipple vor und nach Therapie dargestellt. Im Besonderen wird auf die bei dieser Krankheit seit 1961 bekannten Bakterien, ihre ätiologische Bedeutung, Fragen ihrer Strukturchemie sowie die Eigenart der resultierenden Gewebsreaktion eingegangen. Vergleiche zwischen der Morphologie des Darmes und klinischer Symptomatik vor und während der Antibioticumtherapie ergeben ferner erneut Hinweise auf die besondere Bedeutung des Schleimhautepithels für die intestinale Fettresorption.

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Authors and Affiliations

  1. Ludwig Aschoff-Haus, Pathologisches Institut der Universität Freiburg i. Br, Germany

    J. Moppert, L. Bianchi & H. Bühler

  2. Pathologisch-Anatomisches Institut der Universität, Hebelstr. 24, CH-4000, Basel, Schweiz

    J. Moppert

Authors
  1. J. Moppert
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  2. L. Bianchi
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  3. H. Bühler
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Additional information

Bis September 1967 Stipendiat der Forschungskommission der Universität Basel.

Wesentliche Teile der vorliegenden Arbeit werden von FrauBühler als Dissertation der medizinischen Fakultät der Universität Freiburg i. Br. vorgelegt.

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Moppert, J., Bianchi, L. & Bühler, H. Zur Morphologie der Dünndarmschleimhaut bei Morbus Whipple (intestinale Lipodystrophie). Virchows Arch. Abt. A Path. Anat. 344, 307–321 (1968). https://doi.org/10.1007/BF00593540

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  • DOI: https://doi.org/10.1007/BF00593540

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