Abstract
Carmofur, a derivative of 5-fluorouracil, has recently been noted to have an infrequent but serious association with leukoencephalopathy. To our knowledge, there has been no report of early MRI findings in this leukoencephalopathy. We describe a case in which diffuse high signal intensity of the entire cerebral white matter, including the corpus callosum, was seen on T2-weighted magnetic resonance images. Although similar findings can be seen in many other diseases, carmofur-induced leukoencephalopathy should be suspected in a patient treated with carmofur. It is important to know the clinical and MRI characteristics of this condition, for early diagnosis and better prognosis.
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Matsumoto, S., Nishizawa, S., Murakami, M. et al. Carmofur-induced leukoencephalopathy: MRI. Neuroradiology 37, 649–652 (1995). https://doi.org/10.1007/BF00593382
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DOI: https://doi.org/10.1007/BF00593382