, Volume 37, Issue 8, pp 615–623 | Cite as

1H and31P magnetic resonance spectroscopic imaging of white matter signal hyperintensity areas in elderly subjects

  • J. M. Constans
  • D. J. Meyerhoff
  • D. Norman
  • G. Fem
  • M. W. Weiner
Diagnostic Neuroradiology


White matter signal hyperintensities (WMSH) are commonly seen on MRI of elderly subjects. The purpose of this study was to characterize metabolic changes in the white matter of elderly subjects with extensive WMSH. We used water-suppressed proton (1H) magnetic resonance spectroscopic imaging (MRSI) to compare six subjects with extensive WMSH with eight age-matched elderly subjects with minimal or absent WMSH, and phosphorus (31P) MRSI to compare nine subjects with extensive WMSH and seven age-matched elderly subjects without extensive WMSH. Relative to region-matched tissue in elderly controls, extensive WMSH were associated with increased signal from choline-containing metabolites, no significant change of signal fromN-acetylaspartate, and a trend to a decreased phosphomonoester (PME) resonance. These findings suggest that WMSH may be associated with an alteration of brain myelin phospholipids in the absence of axonal damage. There were no differences in energy phosphates, consistent with lack of ongoing brain ischemia. Within the group with extensive WMSH, PME resonance measures were significantly lower in WMSH than in contralateral normal-appearing white matter. These results provide information on pathophysiology of WMSH and a basis for comparison with WMSH in Alzheimer's disease, vascular dementia, multiple sclerosis, and other diseases.

Key words

White matter signal changes Normal aging N-Acetylaspartate Ischemia Magnetic resonance spectroscopic imaging Magnetic resonance imaging 


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • J. M. Constans
    • 1
    • 3
  • D. J. Meyerhoff
    • 1
    • 3
  • D. Norman
    • 3
  • G. Fem
    • 2
    • 5
  • M. W. Weiner
    • 1
    • 3
    • 4
    • 6
  1. 1.Department of Veterans Affairs Medical Center and University of California Magnetic Resonance UnitSan FranciscoUSA
  2. 2.Department of Veterans Affairs Psychiatry ServiceUniversity of CaliforniaSan FranciscoUSA
  3. 3.Department of RadiologyUniversity of CaliforniaSan FranciscoUSA
  4. 4.Department of MedicineUniversity of CaliforniaSan FranciscoUSA
  5. 5.Department of PsychiatryUniversity of CaliforniaSan FranciscoUSA
  6. 6.Magnetic Resonance Spectroscopy UnitDVA Medical CenterSan FranciscoUSA

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