Skip to main content
Log in

Differential action of TEA+ on two K+-current components of a molluscan neurone

  • Published:
Pflügers Archiv Aims and scope Submit manuscript

Summary

Snail neuronal membranes have two distinct outward current components. Both components are carried by K+-ions. They are, however, differentially influenced by Tetraethylammonium. At low concentrations in the external bath (5 mM), TEA+ blocks the delayed outward current only. The fast outward current is affected if higher TEA+ concentrations are used. Intracellular TEA+, applied iontophoretically, blocks both current components in a similar manner.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Alving, B. O.: Differences between pacemaker and nonpacemaker neurons of Aplysia on voltage clamping. J. gen. Physiol.54, 512 (1969).

    Google Scholar 

  • Armstrong, C. M., Binstock, L.: Anomalous rectification in the squid giant axon injected with TEACI. J. gen. Physiol.48, 859–872 (1965).

    Google Scholar 

  • Armstrong, C. M., Hille, B.: The inner quaternary ammonium ion receptor in potassium channels of node of Ranvier. J. gen. Physiol.59, 388–401 (1972).

    Google Scholar 

  • Connor, J. A., Stevens, C. F.: Voltage clamp studies of a transient outward membrane current in gastropod neural somata. J. Physiol. (Lond.)213, 21 (1971).

    Google Scholar 

  • Gola, M., Romey, G.: Responses anomales à des courants sous-liminaires de certaines membranes somatiques (neurons géants d'Helix pomatia). Pflügers Arch.327, 105 (1971).

    Google Scholar 

  • Hagiwara, S., Kusano, K., Saito, N.: Membrane changes of Onchidium nerve cells in Potassium-Rich Media. J. Physiol. (Lond.)155, 470–489 (1961).

    Google Scholar 

  • Hagiwara, S., Saito, N.: Voltage current relations in nerve cell membranes of Onchidium verruculatum. J. Physiol. (Lond.)148, 161–179 (1959).

    Google Scholar 

  • Hille, B.: The selective inhibition of delayed K-currents in nerve by TEA+ ion. J. gen. Physiol.50, 1287–1302 (1967).

    Google Scholar 

  • Hille, B.: Ionic channels in nerve membrane. Progr. Biophys. molec. Biol.21, 1–32 (1970).

    Google Scholar 

  • Koppenhöfer, E.: Die Wirkung von TEACl auf die Membranströme Ranvierscher Schnürringe von Xenopus laevis. Pflügers Arch. ges. physiol.293, 34–55 (1967).

    Google Scholar 

  • Koppenhöfer, E., Vogel, W.: Wirkung von TTX und TEA+ an der Innenseite der Schnürringmembran von Xenopus laevis. Pflügers Arch.313, 361–380 (1969).

    Google Scholar 

  • Levitan, H., Tauc, L.: Acetylcholine receptors: Topographic distribution and pharmacological properties of two receptor types on a single molluscan neurone. J. Physiol. (Lond.)222, 537–558 (1972).

    Google Scholar 

  • Nakajima, S.: Analysis of K-inactivation and TEA action in the supramedullary cells of puffer. J. gen. Physiol.49, 629 (1966).

    Google Scholar 

  • Neher, E.: Two fast transient current components during voltage clamp on snail neurons. J. gen. Physiol.58, 36–53 (1971).

    Google Scholar 

  • Neher, E., Lux, H. D.: Voltage clamp on helix pomatia neuronal membrane; Current measurement over a limited area of the soma surface. Pflügers. Arch.311, 272–277 (1969).

    Google Scholar 

  • Tasaki, I., Hagiwara, S.: Demonstration of two stable potential states in the squid giant axon under TEACl. J. gen. Physiol.40, 859–885 (1957).

    Google Scholar 

  • Vierhaus, J., Ulbricht, W.: Rate of action of TEA+-ions on the duration of action potentials in single Ranvier nodes. Pflügers Arch.326, 88–100 (1971).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Neher, E., Lux, H.D. Differential action of TEA+ on two K+-current components of a molluscan neurone. Pflugers Arch. 336, 87–100 (1972). https://doi.org/10.1007/BF00592924

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00592924

Key words

Navigation