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Localization of gold in biological tissue

A photochemical method for light and electronmicroscopy

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A detailed description is given of a method by which gold can be visualized in frozen, paraffin and Epon sections. Histological sections from animals treated with gold compounds are exposed to UV-light from 30 min to several hours. The reduced, metallic gold is then visualized by means of a photographic developer containing silver lactate. Light- and electronmicroscope photographs showing gold in different organs from rats and mice treated with aurothioglucose, aurothiosulfate and aurothiomalate are presented.

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Danscher, G. Localization of gold in biological tissue. Histochemistry 71, 81–88 (1981).

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