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Histological and immunohistochemical studies of the endocrine cells of the gastrointestinal mucosa of the toad (Bufo regularis)

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Summary

Using histological and immunhistochemical techniques, nine endocrine cell types were observed in the mucosa of the gastrointestinal tract of the toad,Bufo regularis, viz. enterochromaffin, somatostatin, glucagon, pancreatic polypeptide (PP), secretin, gastric inhibitory peptide (GIP), gastrin-C-terminal pentapeptide (GTPP), neurotensin and bombesin cells. The enterochromaffin cells were distributed throughout the gastrointestinal tract except the rectum. Somatostatin, glucagon, PP, secretin, GIP and GTPP cells were observed both in the ileum and bombesin cells only in the pyloric and antral parts of the stomach. Immunostaining of consecutive sections did not reveal more than one polypeptide hormone in any of these cell types. It is concluded from the present results that the toad gastrointestinal mucosa contains endocrine cell types that are more or less homologous to those in the mammal alimentary tract, though some of them exhibit a different topographic distribution.

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Authors and Affiliations

  1. Departments of Pathology and Clinical Chemistry, University Hospital, Box 553, S-751 22, Uppsala, Sweden

    M. El-Salhy, L. Grimelius, E. Wilander, G. Abu-Sinna & G. Lundqvist

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  1. M. El-Salhy
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  2. L. Grimelius
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  3. E. Wilander
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  4. G. Abu-Sinna
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  5. G. Lundqvist
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El-Salhy, M., Grimelius, L., Wilander, E. et al. Histological and immunohistochemical studies of the endocrine cells of the gastrointestinal mucosa of the toad (Bufo regularis). Histochemistry 71, 53–65 (1981). https://doi.org/10.1007/BF00592570

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  • DOI: https://doi.org/10.1007/BF00592570

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