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The course of inhibition of sympathetic activity during various patterns of carotid sinus nerve stimulation

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Summary

In 63 chloralose-urethane anaesthetized dogs both carotid sinus nerves (CSN) and cervical vagal nerves were cut and the sympathetic activity was recorded.

During bilateral CSN-stimulation for 2 min the following pattern of sympathetic inhibition was observed:

  1. a)

    A complete inhibition took place after a latency of 181±23 msec. This initial inhibition increased with increasing stimulation frequency up to a maximal tested frequency of 150/sec.

  2. b)

    After this initial inhibition sympathetic activity increased and reached a steady state level. The time required for this adaptation increased up to stimulation frequencies of 30–40/sec and remained constant at 20–30 sec at higher frequencies. Maximal steady state inhibition was obtained with frequencies of 20–30/sec.

  3. c)

    In comparison to CSN stimulation with continuous and interrupted trains the latter reduced the adaptation and was more effective in steady state inhibition of sympathetic activity.

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This work was supported by the Deutsche Forschungsgemeinschaft.

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Richter, D.W., Keck, W. & Seller, H. The course of inhibition of sympathetic activity during various patterns of carotid sinus nerve stimulation. Pflugers Arch. 317, 110–123 (1970). https://doi.org/10.1007/BF00592496

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