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Influence of additional methyl groups in the Nɛ-amino position of lysine on the renal handling

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Summary

The renal handling and the metabolism of3H-labeled Nɛ-methylatedl-lysines1 were investigated in dogs. In one dog the endogenous clearance of some basic amino acids including methyllysines was measured. In the chicken kidney a possible tubular secretion of TML was checked using the Sperber technique. The following results were obtained:

  1. 1.

    l-MML is reabsorbed in the kidney similar to lysine.

  2. 2.

    l-DML has a smaller renal reabsorption than lysine.

  3. 3.

    The clearance ofl-TML is in the range of the inulin clearance. No evidence for tubular secretion ofl-TML has been obtained.

  4. 4.

    Forl-TML the lowest metabolism of all three methylated lysines has been found.

The different behaviour of methyllysines in the kidney is discussed with respect to their different physico-chemical properties.

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Authors and Affiliations

  1. Institut für Medizinische Strahlenkunde der Universität Würzburg, Germany

    Robert Löwer, Hans-Walter Lange, Christa Eichhorn & Klaus Hempel

Authors
  1. Robert Löwer
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  2. Hans-Walter Lange
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  3. Christa Eichhorn
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  4. Klaus Hempel
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Additional information

This investigation was supported by a grant of the Cusanuswerk for R. L., by the Deutsche Forschungsgemeinschaft and by the Universitätsbund Würzburg.

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Löwer, R., Lange, HW., Eichhorn, C. et al. Influence of additional methyl groups in the Nɛ-amino position of lysine on the renal handling. Pflugers Arch. 347, 159–172 (1974). https://doi.org/10.1007/BF00592397

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  • DOI: https://doi.org/10.1007/BF00592397

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