The mechanism of histamine-induced transcapillary fluid movement
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This study was designed to determine the direct effect of histamine on capillary membrane permeability and pre- and post-capillary resistances. Ten experiments were carried out on isolated forelimbs of dogs perfused with blood oxygenated by aStarling heart-lung preparation. Permeability was determined by measuring the isogravimetric capillary pressure (Pc i ) using a modification of thePappenheimer andSoto-Rivera technique. Histamine was administered by intraarterial infusion in increasing doses, ranging from 2.7 to 68 μg/min. Results show a significant, dose dependent fall of meanPc i from 10.7 to 7.7 mm Hg when histamine was given in a dosage of 6.8 μg/min or higher.
Pre-capillary resistance fell with each histamine dose used in these experiments. No significant change of the post-capillary resistance occurred, except during infusion of histamine at doses between 27 and 68 μg/min.
It is suggested that histamine increases the permeability of the capillaries due to a direct action on the capillary membrane. Additional increases in hydrostatic capillary pressure may contribute to net capillary filtration induced by histamine.
Key-WordsHistamine Isogravimetric Pressure Capillary Permeability Vascular Resistance
SchlüsselwörterHistamin Isogravimetrischer Druck Capillarpermeabilität Gefäßwiderstand
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