Pflügers Archiv

, Volume 309, Issue 1, pp 99–106 | Cite as

The mechanism of histamine-induced transcapillary fluid movement

  • W. Dietzel
  • W. H. Massion
  • L. B. Hinshaw


This study was designed to determine the direct effect of histamine on capillary membrane permeability and pre- and post-capillary resistances. Ten experiments were carried out on isolated forelimbs of dogs perfused with blood oxygenated by aStarling heart-lung preparation. Permeability was determined by measuring the isogravimetric capillary pressure (Pc i ) using a modification of thePappenheimer andSoto-Rivera technique. Histamine was administered by intraarterial infusion in increasing doses, ranging from 2.7 to 68 μg/min. Results show a significant, dose dependent fall of meanPc i from 10.7 to 7.7 mm Hg when histamine was given in a dosage of 6.8 μg/min or higher.

Pre-capillary resistance fell with each histamine dose used in these experiments. No significant change of the post-capillary resistance occurred, except during infusion of histamine at doses between 27 and 68 μg/min.

It is suggested that histamine increases the permeability of the capillaries due to a direct action on the capillary membrane. Additional increases in hydrostatic capillary pressure may contribute to net capillary filtration induced by histamine.


Histamine Isogravimetric Pressure Capillary Permeability Vascular Resistance 


Histamin Isogravimetrischer Druck Capillarpermeabilität Gefäßwiderstand 


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Copyright information

© Springer-Verlag 1969

Authors and Affiliations

  • W. Dietzel
    • 1
    • 2
  • W. H. Massion
    • 1
    • 2
  • L. B. Hinshaw
    • 1
    • 2
  1. 1.Departments of Anesthesiology and PhysiologyUniversity of Oklahoma Medical CenterOklahoma
  2. 2.Veterans Administration Hospital Oklahoma CityOklahoma

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