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Pflügers Archiv

, Volume 309, Issue 1, pp 99–106 | Cite as

The mechanism of histamine-induced transcapillary fluid movement

  • W. Dietzel
  • W. H. Massion
  • L. B. Hinshaw
Article

Summary

This study was designed to determine the direct effect of histamine on capillary membrane permeability and pre- and post-capillary resistances. Ten experiments were carried out on isolated forelimbs of dogs perfused with blood oxygenated by aStarling heart-lung preparation. Permeability was determined by measuring the isogravimetric capillary pressure (Pc i ) using a modification of thePappenheimer andSoto-Rivera technique. Histamine was administered by intraarterial infusion in increasing doses, ranging from 2.7 to 68 μg/min. Results show a significant, dose dependent fall of meanPc i from 10.7 to 7.7 mm Hg when histamine was given in a dosage of 6.8 μg/min or higher.

Pre-capillary resistance fell with each histamine dose used in these experiments. No significant change of the post-capillary resistance occurred, except during infusion of histamine at doses between 27 and 68 μg/min.

It is suggested that histamine increases the permeability of the capillaries due to a direct action on the capillary membrane. Additional increases in hydrostatic capillary pressure may contribute to net capillary filtration induced by histamine.

Key-Words

Histamine Isogravimetric Pressure Capillary Permeability Vascular Resistance 

Schlüsselwörter

Histamin Isogravimetrischer Druck Capillarpermeabilität Gefäßwiderstand 

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References

  1. Baker, C. H.: Vascular volume changes following histamine release in the dog forelimb. Amer. J. Physiol.211, 661–666 (1966).Google Scholar
  2. Diana, J. N., J. Schwinghamer, andS. Young: Direct effect of histamine on arterial and venous resistance in isolated dog hindlimb. Amer. J. Physiol.214, 494–505 (1968).Google Scholar
  3. Ebert, R. H., andR. C. Graham: Observations on the effect of histamine and serotonin in the rabbit ear chamber. Angiology17, 402–410 (1966).Google Scholar
  4. Gaddum, J. H.: Histamine. Brit. med. J.1948, 867–873.Google Scholar
  5. Grant, R. T.: Direct observation of skeletal muscle blood vessel (rat cremaster). J. Physiol. (Lond.)172, 123–137 (1964).Google Scholar
  6. Haddy, F. J.: Effect of histamine on small and large vessel pressures in the dog foreleg. Amer. J. Physiol.198, 161–168 (1960).Google Scholar
  7. Hanson, K. M., andP. C. Johnson: Evidence for local arteriovenous reflex in intestine. J. appl. Physiol.17, 509–513 (1962).Google Scholar
  8. Holobut, W.: Effect of different doses of histamine upon the peripheral blood levels of adrenaline and noradrenaline. Arch. int. Pharmacodyn.163, 32–37 (1966).Google Scholar
  9. Johnson, P. C., K. M. Hanson, andO. Thulesius: Pre- and post-capillary resistance in the dog forelimb. Amer. J. Physiol.210, 873–876 (1966).Google Scholar
  10. Knowlton, F. P., andE. H. Starling: The influence of variations in temperature and blood pressure on the performance of the isolated mammalian heart. J. Physiol. (Lond.)44, 206–219 (1912).Google Scholar
  11. Majno, G., V. Gilmore, andM. Leventhal: On the mechanism of vascular leakage caused by histamine-type mediators. Circulat. Res.21, 833–847 (1967).Google Scholar
  12. Majno, G., andM. Leventhal: Pathogenesis of “histamine-type” vascular leakage. Lancet1967 I, 99–100.Google Scholar
  13. —, andG. I. Schoefl: Studies on inflammation. II. Site of action of histamine and serotonin on the vascular tree: a topographic study. J. biophys biochem. Cytol.11, 607–626 (1961).Google Scholar
  14. Manger, W., J. Bollmann, F. Maher, andJ. Berkson: Plasma concentration of epinephrine and norepinephrine in hemorrhagic and anaphylactic shock. Amer. J. Physiol.190, 310–316 (1957).Google Scholar
  15. Pappenheimer, J. R., andA. Soto-Rivera: Effective osmotic pressure of the plasma proteins and other quantities associated with the capillary circulation in the hindlimbs of cats and dogs. Amer. J. Physiol.152, 471–491 (1948).Google Scholar
  16. Rowley, D. A.: Venous constriction as the cause of increased permeability produced by 5-hydroxytryptamine, histamine, bradykinin and 48/80 in the rat. Brit. J. exp. Path.45, 56–67 (1964).Google Scholar
  17. Stish, R. J., L. D. Maclean, andM. B. Visscher: A device for continuous recording of weight change suitable for physiological measurements. J. appl. Physiol.9, 297–298 (1956).Google Scholar
  18. Taichman, N. S., andP. Goldhaber: Microcirculatory stasis and the production of tissue necrosis in the hamster cheek pouch induced by histamine or a histamine liberator. Angiology15, 515–523 (1964).Google Scholar
  19. Wiederhielm, C. A.: Transcapillary and interstitial transport phenomena in the mesentery. Fed. Proc.25, 1789–1798 (1966).Google Scholar
  20. Zweifach, B. W., andM. Intaglietta: Fluid exchange across the blood capillary interface. Fed. Proc.25, 1784–1788 (1966).Google Scholar

Copyright information

© Springer-Verlag 1969

Authors and Affiliations

  • W. Dietzel
    • 1
    • 2
  • W. H. Massion
    • 1
    • 2
  • L. B. Hinshaw
    • 1
    • 2
  1. 1.Departments of Anesthesiology and PhysiologyUniversity of Oklahoma Medical CenterOklahoma
  2. 2.Veterans Administration Hospital Oklahoma CityOklahoma

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