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Pflügers Archiv

, Volume 309, Issue 1, pp 38–47 | Cite as

O2 consumption and metabolite balance in the dog gastrocnemius at rest and during exercise

  • P. E. di Prampero
  • P. Cerretelli
  • J. Piiper
Article

Summary

In a gastrocnemius muscle “in situ” performing isotonic contractions, blood flow, O2 consumption, CO2 production, the balance of glucose, lactic acid, free fatty acids and total esterified fatty acids were measured. The RQ increased from a resting value of 0.75 to a value of 0.89 at the highest exercise levels. The net glucose uptake from blood (glucose uptake-lactic acid output) could account, at rest, for 53%, and during exercise, for 30% of the total O2 uptake. The uptake of free fatty acids was practically nil at rest, while it could account for about 15% of the O2 consumed at exercise. Comparison of the metabolites balance with the energy contributed by oxidation of carbohydrates and lipids, as computed from\(\dot V_{{\text{O}}_{\text{2}} }\) and RQ, provides evidence for a sizable storage of carbohydrates in the resting muscle, for a depletion of the stores during exercise and for oxidation of a substrate, probably lipid stored in the muscle, resulting in a low RQ.

Key-Words

Muscle Metabolism Free Fatty Acids Glucose Lactic Acid Respiratory Quotient 

Schlüsselwörter

Muskel-Stoffwechsel Freie Fettsäuren Glucose Milchsäure Respiratorischer Quotient 

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Copyright information

© Springer-Verlag 1969

Authors and Affiliations

  • P. E. di Prampero
    • 1
    • 2
  • P. Cerretelli
    • 1
    • 2
  • J. Piiper
    • 1
    • 2
  1. 1.Department of PhysiologyUniversity of MilanMilanItaly
  2. 2.Department of PhysiologyMax Planck Institute for Experimental MedicineGöttingenGermany

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