Pflügers Archiv

, Volume 334, Issue 4, pp 293–302 | Cite as

Mesure de la vitesse de renouvellement du lactate chez le rat par perfusion de 14-C-U (l) lactate

  • A. Freminet
  • E. Bursaux
  • C. F. Poyart

Lactate turnover in rats using14C-U-(l) lactate


  1. 1.

    Lactate turnover was measured in 24 anesthetized rats using14C-U-(l) Lactate with the priming dose-infusion technique.

  2. 2.

    14C Lactate in blood was determined with a specific radio-enzymatic micromethod.

  3. 3.

    Lactate turnover increases with blood lactate concentration in the range 0.5 to 3 mM. In a steady state system this relationship means that a new equilibrium may be achieved at a higher pool level, between lactate production and utilization.

  4. 4.

    Comparing available data in four mammalian species lactate turnover at normal lactate levels was found to be approximately constant when computed on a body surface unit basis.


Key words

Lactate Turnover l-Lactate14C (U) Hypoxaemia Rat 


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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • A. Freminet
    • 1
  • E. Bursaux
    • 1
  • C. F. Poyart
    • 1
  1. 1.Institut d'AnesthésiologieParis 6 e(France)

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