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Endoscopic clearance of the pancreatic duct in chronic pancreatitis with severe pain

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Summary

In a phase I study endoscopic removal of pancreatic duct stones and protein plugs was attempted in five patients suffering from chronic pancreatitis with severe chronic pain. The pancreatic duct contents could be extracted after successful sphincterotomy in three patients. Clearance of the pancreatic duct was followed by complete or partial relief of pain. The follow-up period was 17–48 months. Endoscopic extraction is, however, not without complications; it is technically difficult, and many attempts may be required. The combination of endoscopic therapy and extracorporeal shock-wave lithotripsy may be a better alternative.

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References

  1. Ammann RW, Muench R, Otto R, Buehler H, Freiburghaus AU, Siegenthaler W (1988) Evolution and regression of pancreatic calcification in chronic pancreatitis. Gastroenterology 95: 1018–1028

    Google Scholar 

  2. Beger HG, Buchler M, Bittner RR, Oettinger W, Roscher R (1989) Duodenum-preserving resection of the head of the pancreas in severe chronic pancreatitis. Ann Surg 209: 273–278

    Google Scholar 

  3. Bernard JP, Sahel J, Giovannini M, Sarles H (1990) Pancreas divisum is a probable cause of acute pancreatitis: A report of 137 cases. Pancreas 5: 248–254

    Google Scholar 

  4. Bockman DE, Buchler M, Malfertheiner P, Beger HG (1988) Analysis of nerves in chronic pancreatitis. Gastroenterology 94: 1459–1469

    Google Scholar 

  5. Bornman PC, Marks IN, Girdwood AH (1980) Is pancreatic duct obstruction or stricture a major cause of pain in calcific pancreatitis? Br J Surg 67: 425–428

    Google Scholar 

  6. Burdick JS, Hogan WJ (1991) Chronic pancreatitis: selection of patients for endoscopic therapy. Endoscopy 23: 155–159

    Google Scholar 

  7. Cremer M, Devière J, Delhaye M, Baize M, Vandermeeren A (1991) Stenting in severe chronic pancreatitis: Results of medium-term follow-up in seventy-six patients. Endoscopy 23: 171–176

    Google Scholar 

  8. Delhaye M, Vandermeeren A, Baize M, Cremer M (1992) Extracorporeal schock wave lithotripsy of pancreatic calculi: a new approach for the management of chronic pancreatitis. Gastroenterology 102: 610–620

    Google Scholar 

  9. Frey CF, Suzuki M, Isaji S, Zhu Y (1989) Pancreatic resection for chronic pancreatitis. Surg Clin North Am 69: 499–528

    Google Scholar 

  10. Fuji T, Amano H, Harima K, Aibe T, Asagami F, Kinukawa K, Ariyama S, Takemoto T (1985) Pancreatic sphincterotomy and pancreatic endoprosthesis. Endoscopy 17: 69–72

    Google Scholar 

  11. Geenen JE (1988) A/S/G/E Distinguished lecture — Endoscopic therapy of pancreatic disease: a new horizon. Gastrointest Endosc 34: 386–389

    Google Scholar 

  12. Huibregtse K, Schneider B, Vrij AA, Tytgat GNJ (1988) Endoscopic pancreatic drainage in chronic pancreatitis. Gastrointest Endosc 34: 9–15

    Google Scholar 

  13. Kennedy RH, Bockman DE, Uscanga L, Choux R, Grimaud J-A, Sarles H (1987) Pancreatic extracellular matrix alterations in chronic pancreatitis. Pancreas 2: 61–72

    Google Scholar 

  14. Klöppel G (1990) Pathology of chronic pancreatitis and pancreatic pain. Acta Chir Scand 156: 261–265

    Google Scholar 

  15. Malfertheiner P, Buchler M (1991) Indications for endoscopic or surgical therapy in chronic pancreatitis. Endoscopy 23: 185–190

    Google Scholar 

  16. McCarthy J, Geenen JE, Hogan WJ (1988) Preliminary experience with endoscopic stent placement in benign pancreatic diseases. Gastrointest Endosc 34: 16–18

    Google Scholar 

  17. Moore EW, Verine HJ (1987) Pancreatic calcification and stone formation: a thermodynamic model of calcium in pancreatic juice. Am J Physiol 252: G707–G718

    Google Scholar 

  18. Multigner L, Sarles H, Lombardo D, De Caro A (1985) Pancreatic stone protein. II. Implication in stone formation during the course of chronic calcifying pancreatitis. Gastroenterology 89: 387–391

    Google Scholar 

  19. Okazaki K, Yamamoto Y, Kagiyama S, Tamura S, Sakamoto Y, Nakazava Y, Morita M, Yamamoto Y (1988) Pressure of papillary sphincter zone and pancreatic main duct in patients with chronic pancreatitis in the early stage. Scand J Gastroenterol 23: 501–506

    Google Scholar 

  20. Ponsky JL, Duppler DW (1987) Endoscopic sphincterotomy and removal of pancreatic duct stones. Am Surg 53: 613–616

    Google Scholar 

  21. Rolny P, Ärlebäck A, Järnerot G, Andersson T (1986) Endoscopic manometry of the sphincter of Oddi and pancreatic duct in chronic pancreatitis. Scand J Gastroenterol 21: 415–420

    Google Scholar 

  22. Sarles H (1984) Epidemiology and physiopathology of chronic pancreatitis and the role of the pancreatic stone protein. Clin Gastroenterol 13: 895–912

    Google Scholar 

  23. Satterfield ST, McCarthy JH, Geenen JE, Hogan WJ, Venu RP, Dodds WJ, Johnson GK (1988) Clinical experience in 82 patients with pancreas divisum: Preliminary results of manometry and endoscopic therapy. Pancreas 3: 248–253

    Google Scholar 

  24. Sauerbruch T (1990) Extracorporeal shock wave lithotripsy of pancreatic calculi. Leber Magen Darm 20: 146–148

    Google Scholar 

  25. Sauerbruch T, Holl J, Sackmann M, Paumgartner G (1992) Extracorporeal lithotripsy of pancreatic stones in patients with chronic pancreatitis and pain. A prospective follow-up study. Gut 33: 969–972

    Google Scholar 

  26. Schneider MU, Lux G (1985) Floating pancreatic duct concrements in chronic pancreatitis. Endoscopy 17: 8–10

    Google Scholar 

  27. Sherman S, Lehman GA, Hawes RH, Ponich T, Miller LS, Cohen LB, Kortan P, Haber GB (1991) Pancreatic ductal stones: Frequency of successful removal and improvement in symptoms. Gastrointest Endosc 37: 511–517

    Google Scholar 

  28. Shuman BM (1988) Stenting the pancreatic duct — for better or worse? Gastrointest Endosc 34: 65–66

    Google Scholar 

  29. Trede M, Schwall G, Saeger H-D (1990) Survival after pancreatoduodenectomy. Ann Surg 211: 447–458

    Google Scholar 

  30. Venu RP, Geenen JE, Hogan W, Stone J, Johnson GK, Soergel K (1989) Idiopathic recurrent pancreatitis: An approach to diagnosis and treatment. Dig Dis Sci 34: 56–60

    Google Scholar 

  31. Warshaw AL, Popp JW, Schapiro RH (1980) Long-term patency, pancreatic function, and pain relief after lateral pancreaticojejunostomy for chronic pancreatitis. Gastroenterology 79: 289–293

    Google Scholar 

  32. Wiechel KL (1986) Percutan-transhepatische Eingriffe. In: Hess W, Cirenei A, Rohner A, Avkovbiantz A (eds) Die Erkrangungen der Gallenwege und des Pancreas, Tome II. Piccin Padua, pp 1491–1525

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Linder, S., Engström, CF., von Rosen, A. et al. Endoscopic clearance of the pancreatic duct in chronic pancreatitis with severe pain. Surg Endosc 7, 37–41 (1993). https://doi.org/10.1007/BF00591235

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