Human Genetics

, Volume 75, Issue 2, pp 189–190 | Cite as

Genetic risk and recombination fraction —an example of non-monotonic dependency

  • Michael Krawezak
Short Communications


The carrier risk for a monogenic disease is not generally monotonously dependent on the recombination fraction between the disease locus and a single marker locus.


Internal Medicine Metabolic Disease Genetic Risk Disease Locus Marker Locus 


  1. Ott J (1976) A computer program for linkage analysis of general human pedigrees. Am J Hum Genet 28:528–529Google Scholar
  2. Ott J (1985) Analysis of human genetic linkage. Johns Hopkins University Press, BaltimoreGoogle Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • Michael Krawezak
    • 1
  1. 1.Institut für Humangenetik der UniversitätGöttingenFederal Republic of Germany

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