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Localization of a human heat-shock HSP 70 gene sequence to chromosome 6 and detection of two other loci by somatic-cell hybrid and restriction fragment length polymorphism analysis

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Summary

The human 70 kdalton heat-shock protein (HSP 70) is a member of a multigene family which is expressed in response to various physiological stresses including elevated temperatures. Using a cloned genomic HSP 70 DNA sequence we demonstrate by somatic cell hybrid and restriction fragment length polymorphism (RFLP) analyses that there are a minimum of three distinct HSP 70 loci in the human genome, one of which is located on chromosome 6.

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Authors and Affiliations

  1. Neurochemistry Department, Institute of Neurology, University of London, Queen Square, WC1N 3BG, London, UK

    Alison M. Goate, David N. Cooper, Christine Hall, Thomas K. C. Leung & Louis Lim

  2. The Imperial Cancer Research Fund, Lincoln's Inn Fields, WC2A 3PX, London, UK

    Ellen Solomon

Authors
  1. Alison M. Goate
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  2. David N. Cooper
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  3. Christine Hall
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  4. Thomas K. C. Leung
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  5. Ellen Solomon
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  6. Louis Lim
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Goate, A.M., Cooper, D.N., Hall, C. et al. Localization of a human heat-shock HSP 70 gene sequence to chromosome 6 and detection of two other loci by somatic-cell hybrid and restriction fragment length polymorphism analysis. Hum Genet 75, 123–128 (1987). https://doi.org/10.1007/BF00591072

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  • DOI: https://doi.org/10.1007/BF00591072

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