Abstract
We examined the molecular basis for rabbit C8α-γ deficiency (C8D) using human C8 cDNA probes. Sequential probing of normal rabbit poly(A)+RNA revealed messages of 2.1, 1.9, and 0.8 kb for α, β, and γ, respectively. Corresponding analysis of C8D rabbit poly(A)+RNA identified messages for α and γ of the same size and amounts as normal rabbits. Thus, C8α-γ deficiency in the rabbit appears to be the result of a translational rather than a transcriptional defect.
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This work was supported in part by NIH Grants AI16856 and GM42898 awarded to J.M.S.
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Komatsu, M., Yamamoto, KI., Mikami, H. et al. Genetic deficiency of complement component C8 in the rabbit: Evidence of a translational defect in expression of the α-γ subunit. Biochem Genet 29, 271–274 (1991). https://doi.org/10.1007/BF00590107
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DOI: https://doi.org/10.1007/BF00590107