Pflügers Archiv

, Volume 336, Issue 3, pp 237–248 | Cite as

Effects of pyridoxine deficiency on rat intracellular cardiac action potentials

  • T. Ceriani
  • U. Ventura
  • V. Molina
  • G. Rindi


Ventricular myocardial cell action potentials were measuredin situ by means of intracellular microelectrodes in the heart of pyridoxine-deficient rats both at spontaneous frequency and at frequencies increased to higher levels. Pyridoxine deficiency lowered the rates of depolarization and repolarization phases of ventricular action potentials thus lengthening their duration. A noticeable bradycardia seemed to be induced by pyridoxine deficiency.

The modifications of ventricular action potentials and of frequency were coupled with a decrease of vitamin B6 in the heart. Ventricular action potentials of pyridoxine-supplemented rats appeared to be largely restored to their normal parametes by pyridoxine administration. Pyridoxine-supplementation had also a remarkable effect upon frequency of the pyridoxine-deficient hearts since it reversed bradycardia to a striking tachycardia.

Key words

Pyridoxine Deficiency in Rat Ventricular Intracellular Action Potentials Pyridoxine Heart Rate 


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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • T. Ceriani
    • 1
  • U. Ventura
    • 1
  • V. Molina
    • 1
  • G. Rindi
    • 1
  1. 1.Institute of Human PhysiologyUniversity of PaviaPaviaItaly

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