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Cocaine enhances memory storage in mice


Mice were trained on a one-trial inhibitory avoidance task and given immediate post-training intraperitoneal injections of cocaine (0.03–1.00 mg/kg). On a retention test 24 h later, the retention latencies of mice given the 0.10 mg/kg dose were significantly higher than those of the controls. The effect of cocaine on retention was time-dependent: retention latencies were not altered in animals given cocaine 60 min after training. Administration of cocaine (0.1 mg/kg) prior to the retention test did not modify the retention performance of mice that received either saline or cocaine (0.1 mg/kg) immediately post-training. The findings suggest that cocaine affects retention by influencing post-training processes involved in memory storage.

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Correspondence to Ines B. Introini-Collison.

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Introini-Collison, I.B., McGaugh, J.L. Cocaine enhances memory storage in mice. Psychopharmacology 99, 537–541 (1989).

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Key words

  • Cocaine
  • Memory
  • State-dependency
  • Cocaine and reward
  • Catecholamines