Summary
Replicate slides of autopsy specimens (kidney, pancreas, adrenal glands, and liver) from 66 hospital patients who had lengthy outpatient records of their blood pressure levels were randomized and graded blindly for the severity of hypertensive fibroproliferative-mediodegeneration lesions of arterioles (arplasia). For all four tissues, the severity of lesions correlated significantly with the level of the blood pressure. Between blood pressure and lesions the correlation coefficient was significantly smaller (P<0.01) for liver and adrenal than for kidney. The correlation coefficient was also smaller for pancreas than for kidney, but the statistical significance of the difference (0.3>P>0.2) was not conclusive. The results tend to confirm the conclusions of the classic 1937 report of Moritz and Oldt, adding strength to their generalization that “Arteriolar sclerosis is the most common cause of chronic hypertension.”
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References
Coleman TG, Guyton AC, Young EB, DeClue JW, Norman RA, Manning RD (1975) The role of the kidney in essential hypertension. Clin Exp Pharm Physiol 12:571–581
Dunn OJ, Clark V (1971) Comparison of tests of the equality of dependent correlation coefficients. J Am Statistical Assoc 66:904–908
Fishberg AM (1925) Anatomic findings in essential hypertension. Arch Intern Med 35:650–668
Moritz AR, Oldt MR (1937) Arteriolar sclerosis in hypertensive and non-hypertensive individuals. Am J Pathol 13:679–728
Mowry RW (1960) Alcian blue and alcian blue-periodic acid Schiff stains for carbohydrate. AFIP Manual of Histologic and Special Staining Technics, 2nd edn. Armed Forces Institute of Pathology Washington p 142–144
Short D (1966) The vascular fault in chronic hypertension. Lancet 2:1302–1304
Short D (1967) The nature of the increased vascular resistance in chronic hypertension. Am Heart J 73:840–841
Stoddard LD, Puchtler H (1969) Human renal vascular lesions and hypertension. Pathol Ann 4:253–268
Tracy RE (1970a) Correlation of lengthy hospital records of blood pressure with nephrosclerosis. Am J Epidemiol 91:32–37
Tracy RE (1970b) Quantitative measures of the severity of hypertensive nephrosclerosis. Am J Epidemiol 91:25–31
Tracy RE (1970c) Weighted means of systolic and diastolic blood pressure in the comparison of direct with indirect measurements. Am J Epidemiol 91:21–24
Tracy RE, Overll EO (1966) Arterioles of perfusion-fixed hypertensive and aged kidneys. Arch Pathol 82:526–534
Tracy RE, Tabares Toca V (1974a) Nephrosclerosis and blood pressure: I. Rising and falling patterns in lengthy records. Lab. Invest. 30:20–29
Tracy RE, Tabares Toca V (1974b) Nephrosclerosis and blood pressure II. Reversibility of proliferative arteriosclerosis. Lab Invest 30:30–34
Walker HM, Lev J (1953) Statistical inference. Henry Holt and Company New York p 299–301
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Supported by Grants HE-08974, HE-10372, HL-12583, HL-12913, and HL-14496 from the US Public Health Service
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Tracy, R.E., Johnson, W.D., Lopez, C.R. et al. Hypertension and arteriolar sclerosis of the kidney, pancreas, adrenal gland, and liver. Virchows Arch. A Path. Anat. and Histol. 391, 91–106 (1981). https://doi.org/10.1007/BF00589797
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DOI: https://doi.org/10.1007/BF00589797