Pflügers Archiv

, Volume 336, Issue 1, pp 48–59 | Cite as

The components of the sodium efflux in cardiac Purkyně fibres

  • Suzanne Bosteels
  • E. Carmeliet


  1. 1.

    A study was made of sodium efflux from cardiac Purkyně fibres, and its sensitivity to external Na, K, pH and to inhibitors of the sodium pump.

  2. 2.

    Na efflux was found to be relative insensitive to Ke. When the external K concentration was suddenly increased, the rate coefficient rose only temporarily.

  3. 3.

    In contrast, the Na efflux seemed to be sensitive to the external Na. In zero sodium one third of the efflux was blocked.

  4. 4.

    This Nae-sensitive efflux is completely blocked by ethacrynic acid, reduced by ouabain and not modified by doubling the internal Na.

  5. 5.

    Acidification of the bathing fluid decreased the Na efflux if the preparation was bathed in Na- or choline-Tyrode. In the presence of ouabain the pH effect disappeared.


Key words

Cardiac Cells Components of Na Efflux Active Transport Exchange Diffusion 


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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • Suzanne Bosteels
    • 1
  • E. Carmeliet
    • 1
    • 2
  1. 1.Institute of PhysiologyUniversity of LouvainLouvainBelgium
  2. 2.Laboratorium voor FysiologieLouvainBelgium

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