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Acidification of phosphate buffer in cortical tubules of rat kidney

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Summary

Rate of tubular hydrogen ion secretion was measured by a new method combining stationary microperfusion methods and the continuous measurement of pH changes of phosphate buffer with an antimony electrode. Significant differences in rate of acidification and transepithelial steady-state hydrogen ion gradients were observed in proximal and distal tubules in various acid-base abnormalities.

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References

  1. Gertz, K. H.: Transtubuläre Natriumchloridflüsse und Permeabilität für Nichtelektrolyte im proximalen und distalen Konvolut der Rattenniere. Pflügers Arch. ges. Physiol.276, 336–356 (1963).

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  2. Malnic, G., Mello-Aires, G.: Kinetic study of bicarbonate reabsorption in proximal tubule of the rat. Amer. J. Physiol.220, 1759–1767 (1971).

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  3. Vieira, F. L., Malnic, G.: Hydrogen ion secretion by rat renal cortical tubules as studied by an antimony microelectrode. Amer. J. Physiol.214, 710–718 (1968).

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Authors and Affiliations

  1. Department of Physiology, São Paulo University Medical School, São Paulo, Brasil

    G. Malnic, M. Mello-Aires, G. B. de Mello & G. Giebisch

  2. Department of Physiology, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, Connecticut, USA

    G. Malnic, M. Mello-Aires, G. B. de Mello & G. Giebisch

Authors
  1. G. Malnic
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  2. M. Mello-Aires
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  3. G. B. de Mello
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  4. G. Giebisch
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Malnic, G., Mello-Aires, M., de Mello, G.B. et al. Acidification of phosphate buffer in cortical tubules of rat kidney. Pflugers Arch. 331, 275–278 (1972). https://doi.org/10.1007/BF00589134

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  • DOI: https://doi.org/10.1007/BF00589134

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