Pflügers Archiv

, Volume 331, Issue 3, pp 226–232 | Cite as

Juxtaglomerular granules of the newborn rat kidney

  • D. Schmidt
  • W. G. Forssmann
  • R. Taugner


Differential centrifugation of newborn rat kidney homogenate produced a fraction containing juxtaglomerular granules. The granular fraction had a pressor activity 7.4 times higher per mg protein than the respective homogenate. Electron microscopy showed juxtaglomerular granules in both the epitheloid cells of the juxtaglomerular apparatus and the granular fraction. It is concluded that the concept of newborn rat kidney as an agranular model for the investigation of production and release of renin has to be modified.

Key words

Juxtaglomerular Granules Renin Newborn Rat Kidney Subcellular Fractionation 


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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • D. Schmidt
    • 1
    • 2
  • W. G. Forssmann
    • 1
    • 2
  • R. Taugner
    • 1
    • 2
  1. 1.I. Physiologisches Institut der Universität HeidelbergHeidelberg 1(Germany)
  2. 2.Anatomisches Institut der Universität Heidelberg(Germany)

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