Pflügers Archiv

, Volume 394, Issue 3, pp 222–225 | Cite as

NaCl transport across hen colon

Dependence on electro-chemical driving force
  • K. Holtug
  • E. Skadhauge
Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands


  1. 1.

    Sheets of isolated mucosa from the colon of chickens on either a high or a low NaCl diet were mounted in Ussing chambers. They were bathed in Krebs-phosphate medium and exposed to sodium concentrations ranging from 3.0 to 140 mmol/l (choline-chloride replacement).

  2. 2.

    In the short-circuited state the net fluxes of sodium in the mucosa (m)-serosa (s) direction, followed saturation kinetics withK m =25 mmol/l in the low-NaCl chickens and 124 mmol/l in the high-NaCl chickens.

  3. 3.

    The unidirectional fluxes of sodium in the s-m direction were linearly related to the electro-chemical driving force. The apparent permeabilities were 8.6±0.3×10−6cm/s in the low-NaCl and 11.6±0.3×10−6cm/s in the high-NaCl birds.

  4. 4.

    The chloride fluxes were in the short-circuited state of equal magnitude in the m-s and the s-m direction, and in the two dietary states. Changes in the electrical driving force resulted in changes in chloride fluxes compatible with passive flow.


Key words

Intestine NaCl transport Bird osmoregulation 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • K. Holtug
    • 1
  • E. Skadhauge
    • 1
  1. 1.Department of Medical Physiology A, The Panum InstituteUniversity of CopenhagenCopenhagen NDenmark

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