Pflügers Archiv

, Volume 362, Issue 1, pp 55–59 | Cite as

The dilatatory action of adenosine on pial arteries of cats and its inhibition by theophylline

  • Michael Wahl
  • Wolfgang Kuschinsky


The effect of adenosine upon pial resistance vessels was studied using local microapplication from the perivascular side and measurement of vascular diameter. Concentration-response curves revealed a concentration-dependent dilatatory effect of adenosine between 10−7 and 10−3 M. The degree of dilatation was independent of initial vessel size (47–260 μ). The dilatations due to adenosine could be reduced by theophylline in a reversible competitive antagonism. Concentration-response curves for theophylline yielded no vascular reaction at concentrations of up to 10−5 M theophylline. From these data it is concluded that the pial arterial resting tone is not influenced under our experimental conditions by adenosine formed and released by brain tissue. The dilatations measured at high theophylline concentrations are apparently due to a mechanism different from the adenosine antagonism.

Key words

Pial arterial resistance Arterial resting tone Metabolic factors Cerebral blood flow Local regulation of pial arterial diameter 


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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Michael Wahl
    • 1
  • Wolfgang Kuschinsky
    • 1
  1. 1.Physiologisches Institut der UniversitätMünchenGermany

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