, Volume 32, Issue 2, pp 142–145 | Cite as

Hereditary cerebral hemorrhage with amyloidosis-Dutch type

Tc-99m HM-PAO single photon emission computed tomography
  • J. Haan
  • M. J. P. G. van Kroonenburgh
  • P. R. Algra
  • O. J. S. Buruma
  • E. K. J. Pauwels
  • B. R. Bloem
  • R. A. C. Roos


We performed single photon emission computed tomography (SPECT) and cerebral CT-scans in nine patients with hereditary cerebral amyloid angiopathy. CT-scans showed 23 focal hypodense lesions, 13 of which were visible on SPECT as a CBF-defect. One patient showed a CBF-defect on SPECT without CT-scan lesion and had a cerebral hemorrhage three months later in that particular region. In two additional patients, who were 50% at risk for this autosomal dominant disease, CBF-defects on SPECT, but no cortical lesions on CT-scan were found. CT-scans may be more sensitive than SPECT to detect chronic lesions caused by cerebral hemorrhages, but another possibility is that hemorrhages do not always lead to persistent CBF-defects. SPECT can show the effect of amyloid deposits on CBF before the angiopathy causes clinical symptoms.

Key words

SPECT Tc-99m HM-PAO Hereditary cerebral hemorrhage with amyloidosis 


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • J. Haan
    • 1
  • M. J. P. G. van Kroonenburgh
    • 2
  • P. R. Algra
    • 3
  • O. J. S. Buruma
    • 1
  • E. K. J. Pauwels
    • 2
  • B. R. Bloem
    • 1
  • R. A. C. Roos
    • 1
  1. 1.Department of NeurologyUniversity Hospital LeidenThe Netherlands
  2. 2.Department of Nuclear MedicineUniversity Hospital LeidenThe Netherlands
  3. 3.Department of NeuroradiologyUniversity Hospital LeidenThe Netherlands

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