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The effect of light deprivation on the electro retinogram of the guinea pig

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Zusammenfassung

Die b-Welle im ERG von Meerschweinchen, die in Dunkelheit geboren und 3 Monate lang aufgezogen wurden, ist merklich kleiner als bei Tieren gleichen Alters, die unter normalen Umständen aufgezogen wurden. Eine 10 Tage dauernde Einwirkung von Raumlicht stellt das ERG weitgehend wieder her. Das ERG von 4 Tage alten lichtentzogenen Tieren ist normal entwickelt. Ein 3 Monate langer Lichtentzug hat relativ geringe Wirkung auf normal aufgezogene erwachsene Tiere.

Aus diesen Versuchen wird geschlossen, daß die ursprüngliche ERG-Entwicklung beim Meerschweinchen durch Lichtentzug nicht gestört wird. Hingegen ist das bereits entwickelte ERG von neugeborenen Tieren gegenüber dauerndem Lichtentzug anfälliger als bei erwachsenen Tieren.

Summary

The b-wave in the ERG of guinea pigs born and reared in darkness for three months is considerably smaller than that in animals of the same age reared under normal circumstances.

Exposure to room illumination for ten days greatly restores the ERG. The ERG in four days old light deprived animals is normally developed. A three months light deprivation period causes a relatively small effect in normally raised adult animals.

From these experiments it is concluded that the initial ERG development in the guinea pig is not affected by light deprivation. However, once developed the ERG in new born animals is more vulnerable to prolonged light deprivation than that in adult ones.

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Authors and Affiliations

  1. Department of Physiology, Medical Faculty, Rotterdam, The Netherlands

    C. P. J. J. M. M. Legein & M. W. Van Hof

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  1. C. P. J. J. M. M. Legein
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  2. M. W. Van Hof
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Legein, C.P.J.J.M.M., Van Hof, M.W. The effect of light deprivation on the electro retinogram of the guinea pig. Pflugers Arch. 318, 1–6 (1970). https://doi.org/10.1007/BF00588538

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  • DOI: https://doi.org/10.1007/BF00588538

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