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Towards quantitative measurements of relaxation times and other parameters in the brain

Neuroradiology volume 32, pages 407–415 (1990)Cite this article

Summary

The nature and physical significance of the relaxation times T1 and T2 and of proton density are described. Methods of measuring T1 and T2 are discussed with emphasis on the establishment of precision and the maintenance of accuracy. Reported standards of success are briefly reviewed. We expect sensitivities of the order of 1% to be achievable in serial studies. Although early hopes of disease diagnosis by tissue characterisation were not realised, strict scientific method and careful calibration have made it practicable to apply relaxation time measurement to research into disease process. Serial measurements in patients and correlation with similar studies in animal models, biopsy results and autopsy material taken together have provided new knowledge about cerebral oedema, water compartmentation, alcoholism and the natural history of multiple sclerosis. There are prospects of using measurement to monitor treatment in other diseases with diffuse brain abnormalities invisible on the usual images. Secondarily derived parameters and notably the quantification of blood-brain barrier defect after injection of Gadolinium-DTPA also offer prospects of valuable data.

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References

  1. Damadian R (1971) Tumor detection by nuclear magnetic resonance. Science 171:1151–1153

    Google Scholar 

  2. Foster MA, Hutchinson JMS (eds) (1987) Practical NMR imaging. IRL Press, Oxford Washington

    Google Scholar 

  3. Mathur-De Vre R (1984) Biomedical impliations of the relaxation behaviour of water related to NMR imaging. Br J Radiol 57: 955–976

    Google Scholar 

  4. Bottomley PA, Hardy CJ, Argersinger RE, Allen-Moore G (1987) A review of1H nuclear magnetic resonance relaxation in pathology: Are T1 and T2 diagnostic? Med Phys 14:1–37

    Google Scholar 

  5. Foster KR, Resing HA, Garroway AN (1976) Bounds on “bound water”: transverse nuclear magnetic resonance relaxation in barnacle muscle. Science 194:324–326

    Google Scholar 

  6. Miller DH, Johnson G, Tofts PS, MacManus D, McDonald WI (1989) Precise relaxation time measurements of normal-appearing white matter in inflammatory central nervous system disease. Magn Reson Med 11:331–336

    Google Scholar 

  7. MacFall JR, Wehrli FW, Breger RK, Johnson AJ (1987) Methodology for the measurement and analysis of relaxation times in proton imaging. Magn Reson Imaging 5:209–220

    Google Scholar 

  8. Farrar TC, Becker ED (1971) Pulse and fourier transform NMR. Introduction to theory and methods. Academic Press, New York San Francisco London

    Google Scholar 

  9. Young IR, Bryant DJ, Payne JA (1985) Variations in slice shape and absorption as artifacts in the determination of tissue parameters in NMR imaging. Magn Reson Med 2:355–389

    Google Scholar 

  10. Waterton JC, Checkley D, Jenkins JPR, Naughton A, Zhu XP, Hickey S, Isherwood I (1984) Use of total saturation recovery sequence in magnetic resonance imaging: an improved approach to the measurement of T1. 3rd Annual Meeting of the Society of Magnetic Resonance in Medicine, New York, pp 736–737

  11. Fram EK, Herfkens RJ, Johnson GA, Glover GH, Karis JP, Shimakawa A, Perkins TG, Pelc NJ (1987) Rapid calculation of T1 using variable flip angle gradient refocused imaging. Magn Reson Imaging 5:201–208

    Google Scholar 

  12. Tofts PS, Wicks DAG, Barker GJ (1990) The MRI measurement of physiological parameters in tissue to study disease process. In: Ortendahl D, Lacer J (eds) Information processing in medical imaging. Wiley-Liss, New York, pp 313–326

    Google Scholar 

  13. Knowles RJR, Markisz JA (1988) Quality assurance and image artifacts in magnetic resonance imaging. Little, Brown & Co., Boston Toronto

    Google Scholar 

  14. Dixon RL (ed) (1988) MRI: Acceptance testing and quality control. The role of the clinical medical physicist. Proceedings of the AAPM Symposium held April 6–8, 1988 in Winston-Salem, North Carolina. Medical Physics Publishing Corporation, Madison Wisconsin

    Google Scholar 

  15. Podo F et al. (1988) Identification and characterisation of biological tissues by NMR. Concerted research project of the European Economic Community (6 papers). Magn Reson Imaging 6: 173–222

    Google Scholar 

  16. Holland BA, Haas DK, Norman D, Brant-Zawadzki M, Newton TH (1986) MRI of normal brain maturation. ANJR 7: 201–208

    Google Scholar 

  17. Baierl P, Forster Ch, Fendel H, Naegele M, Fink U, Kenn W (1988) Magnetic resonance imaging of normal and pathological white matter maturation. Pediatr Radiol 18:183–189

    Google Scholar 

  18. Barnes D, McDonald WI, Tofts PS, Johnson G, Landon DN (1986) Magnetic resonance imaging of experimental cerebral oedema. J Neurol Neurosurg Psych 49:1341–1347

    Google Scholar 

  19. Bell BA, Smith MA, Kean DM, McGhee CNJ, MacDonald HL, Miller JD, Barnett GH, Tocher JL, Douglas RHB, Best JJK (1987) Brain water measured by magnetic resonance imaging. Lancet I:66–68

    Google Scholar 

  20. Ormerod IEC, Miller DH, McDonald WI, du Boulay EPGH, Rudge P, Kendall BE, Moseley IF, Johnson G, Tofts PS, Halliday AM, Bronstein AM, Scaravilli F, Harding AE, Barnes D, Zilkha KJ (1987) The role of NMR imaging in the assessment of multiple sclerosis and isolated neurological lesions. A quantitative study. Brain 110:1579–1616

    Google Scholar 

  21. Pykett IL, Rosen BR, Buonanno FS, Brady TJ (1983) Measurement of spin-lattice relaxation times in nuclear magnetic resonance imaging. Phys Med Biol 6:723–729

    Google Scholar 

  22. Bakker CJG, de Graaf CN, van Dijk P (1984) Derivation of quantitative information in NMR imaging: a phantom study. Phys Med Biol 29:1511–1525

    Google Scholar 

  23. Johnson G, Ormerod IEC, Barnes D, Tofts PS, MacManus DG (1987) Accuracy and precision in the measurement of relaxation times from nuclear magnetic resonance images. Br J Radiol 60: 143–153

    Google Scholar 

  24. Condon B, Patterson J, Wyper D, Hadley DM, Jenkins A, Lawrence A, Rowan J (1986) Comparison of calculated relaxation parameters between an MR imager and spectrometer operating at similar frequencies. Magn Reson Imaging 4:449–454

    Google Scholar 

  25. Gowland PA, Leach MO, Sharp JC (1990) The use of an improved inversion pulse with the spin echo/inversion recovery sequence to give increased accuracy and reduced imaging time for T1 measurements. Magn Reson Med 12:261–267

    Google Scholar 

  26. Lerski RA, McRobbie DW, Straughan K, Walker PM, de Certaines JD, Bernard AM (1988) Multi-centre trial with protocols and prototype test objects for the assessment of MRI equipment. Magn Reson Imaging 6:201–214

    Google Scholar 

  27. McRobbie DW (1988) Towards faster reliable T1 quantitation in MRI. Seventh Annual Meeting of the Society of Magnetic Resonance in Medicine, Works-in-progress, p 34

  28. Kjos BO, Ehman RL, Brant-Zawadzki M, Kelly WM, Norman D, Newton TH (1985) Reproducibility of relaxation times and spin density calculated from routine MR imaging sequences: clinical study of the CNS. AJNR 6:271–276

    Google Scholar 

  29. Mander AJ, Smith MA, Kean DM, Chick J, Douglas RHB, Rehman AU, Weppner GJZ, Best JJK (1985) Brain water measured in volunteers after alcohol and vasopressin. Lancet II: 1075

    Google Scholar 

  30. Smith MA, Chick J, Kean DM, Douglas RHB, Singer A, Kendell RE, Best JJK (1985) Brain water in chronic alcoholic patients measured by magnetic resonance imaging (letter). Lancet I:1273–1274

    Google Scholar 

  31. Breger RK, Wehrli FW, Charles HC, MacFall JR, Haughton VM (1986) Reproducibility of relaxation and spin-density parameters in phantoms and the human brain measured by MR imaging at 1.5 T. Magn Reson Med 3:649–662

    Google Scholar 

  32. Lacomis D, Osbakkan M, Gross G (1986) Spin-lattice relaxation (T1) times of cerebral white matter in multiple sclerosis. Magn Reson Med 31:194–202

    Google Scholar 

  33. Besson JAO, Corrigan FM, Cherryman GR, Smith FW (1987) Nuclear magnetic resonance brain imaging in chronic schizophrenia. Br J Psych 150:161–163

    Google Scholar 

  34. Larsson HBW, Frederiksen J, Kjaer L, Henriksen O, Olesen J (1988) In vivo determination of T1 and T2 in the brain of patients with severe but stable multiple sclerosis. Magn Reson Med 7: 43–55

    Google Scholar 

  35. Harvey I, Morris J, Wicks DAG, Tofts PS (1990) Sources of T1 variance in normal appearing human white matter. Magn Reson Imaging (in press)

  36. Haughton VM, Rimm AA, Khatri BO, Papke RA, Breger RK, Fischer ME (1989) Quantitative MR in the diagnosis of multiple sclerosis (abstract). Twenty-seventh Annual Meeting of the American Society of Neuroradiology, Orlando, Florida, March 19–24, 1989. Book of Abstract, pp 244

  37. Ormerod IEC, Johnson G, MacManus D, du Boulay EPGH, McDonald WI (1986) Relaxation times of apparently normal cerebral white matter in multiple sclerosis. Acta Radiol (XIII Symposium [Suppl] 369:382–384

    Google Scholar 

  38. Brainin M, Reisner Th, Maida E, Neuhold A, Wicke L, Lang S, Deecke L (1989) Serial clinical and MRI study of diffuse cerebral white matter changes in multiple sclerosis. In: Nadjmi M (ed.) Imaging of brain metabolism spine and cord interventional neuroradiology free communications. XVth Congress of the European Society of Neuroradiology, Wurzburg, September 13–17 1988. Springer Berlin Heidelberg New York London Paris Tokyo Hong Kong, pp 419–423

    Google Scholar 

  39. Wetterbergk L, Alexius B, Saaf J, Sonnerborg A, Britton S, Pert C (1987) Peptide T in treatment of AIDS. Lancet I:159

    Google Scholar 

  40. Komiyama M, Yagura H, Baba M, Yasui T, Hakuba A, Nishimura S, Inoue Y (1987) MR imaging: possibility of tissue characterisation of brain tumors using T1 and T2 values. AJNR 8:65–70

    Google Scholar 

  41. Fujimoto T, Nakano T, Fujii M, Okada A, Harada K, Yokoyama Y, Uchida T, Tsuji T, Igata A, Asakura T (1987) Changes in proton T1 in dog brains due to the administration of Haloperidol. Magn Reson Imaging 5:469–474

    Google Scholar 

  42. Kermode AG, Tofts PS, Thompson AJ, MacManus DG, Rudge P, Kendall BE, Kingsley DPE, Moseley IF, du Boulay EPGH, McDonald WI (1990) Heterogeneity of blood-brain barrier changes in multiple sclerosis: an MRI study. Neurology 40:229–235

    Google Scholar 

  43. Condon B, Patterson J, Wyper D, Hadley D, Grant R, Teasdale G, Rowan J (1986) Use of magnetic resonance imaging to measure intracranial cerebrospinal fluid volume. Lancet I: 1355–1357

    Google Scholar 

  44. Bakay L, Kurland RJ, Parrish RG, Lee JC, Peng RJ, Bartkowski HM (1975) Nuclear magnetic resonance studies in normal and edematous brain tissue. Exp Brain Res 23:241–248

    Google Scholar 

  45. Gersonde K, Feisberg L, Tolxdorff T, Ratzel D, Strobel B (1984) Analysis of multiple T2 proton relaxation processes in human head and imaging on the basis of selective and assigned T2 values. Magn Reson Med 1:463–477

    Google Scholar 

  46. Schad LR, Brix G, Zuna I, Härle W, Lorenz WJ, Semmler W (1989) Multiexponential proton spin-spin relaxation in MR imaging of human brain tumors. J Comput Assist Tomogr 13: 577–587

    Google Scholar 

  47. Bakker CJG, Vriend J (1984) Multi-exponential water proton spin-lattice relaxation in biological tissues and its implications for quantitative NMR imaging. Phys Med Biol 5:509–518

    Google Scholar 

  48. Tofts PS, Kermode AG (1989a) Measurement of blood brain barrier permeability using Gd-DTPA scanning. Proceedings of Society of Magnetic Resonance Imaging, Los Angeles, February 1989. Magn Reson Imaging 7 [Suppl 1]:150

    Google Scholar 

  49. Tofts PS, Kermode AG (1990) Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging-1 fundamental concepts. Magn Reson Med (in press)

  50. Meier D, Maier S, Bosiger P (1988) Quantitative flow measurements on phantoms and on blood vessels with MR. Magn Reson Med 8:25–34

    Google Scholar 

  51. Bydder GM (1990) Magnetic resonance: perfusion and diffusion imaging. Neuroradiology 32:392–398

    Google Scholar 

  52. Le Bihan D, Moonen CTW, van Zijl PCM, Pekar J, DesPres D (1989) Evaluation of water molecular diffusion and blood microcirculation in the cat brain at 4.7 Tesla. Eighth Annual Meeting of the Society of Magnetic Resonance in Medicine, p 1051

  53. Le Bihan D, Breton E, Lallemand D, Aubin M, Vignaud J, Laval-Jeantet M (1988) Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 168: 497–505

    Google Scholar 

  54. Young IR, Khenia S, Thomas DGT, Davis CH, Gadian DG, Cox IJ, Ross BD, Bydder GM (1987) Clinical magnetic susceptability mapping of the brain. J Comput Assist Tomogr 11: 2–6

    Google Scholar 

  55. Bottomley PA, Foster TH, Leue WM (1984) Chemical imaging of the brain by NMR. Lancet I:1120

    Google Scholar 

  56. Hall LD, Norwood TJ, Williams SCR (1988) Coupled-spin-filtered imaging in an inhomogeneous magnetic field. J Magn Reson 79:363–368

    Google Scholar 

  57. Jenkins JPR, Zhu XP, Whitehouse RW, Isherwood I, Adams JE, Adams PH (1990) Textural analysis of quantitative magnetic resonance imaging (MRI) in metabolic bone disease — an approach to tissue characterisation of the spine. In: Higer, Bielke (eds) Tissue characterisation in MRI. Springer, Berlin Heidelberg New York (in press)

    Google Scholar 

  58. Youl BD, Hawkins CP, Morris JK, Tofts PS, du Boulay EPGH (1990) In vivo dependence of T1 values from guinea pig brain on body temperature. 9th Annual Scientific Meeting SMRM, New York, 18–24 August 1990. Book of Abstracts, vol 1, p 132

    Google Scholar 

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Affiliations

  1. Multiple Sclerosis NMR Research Group, Institute of Neurology, London, England

    P. S. Tofts & E. P. G. H. du Boulay

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  1. P. S. Tofts
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  2. E. P. G. H. du Boulay
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Tofts, P.S., du Boulay, E.P.G.H. Towards quantitative measurements of relaxation times and other parameters in the brain. Neuroradiology 32, 407–415 (1990). https://doi.org/10.1007/BF00588474

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  • DOI: https://doi.org/10.1007/BF00588474

Key words

  • Relaxation times
  • Quantification
  • Methodology
  • Tissue characterisation