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Magnetic resonance: perfusion and diffusion imaging

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Summary

The use of magnetic resonance imaging to detect normal and pathological problems of perfusion and diffusion is reviewed. Motion sensitised spin-echo images can be used to detect changes in slow flow velocity within a voxel (intravoxel coherent motion (IVCM) as well as intravoxel incoherent motion (IVIM) effects attributable to both diffusion and perfusion. Changes have been identified in a variety of brain diseases in the absence of changes in conventional images but the techniques are very vulnerable to motion artefact of all types. More rapid and more sensitive approaches using steady state free precision and echo-planer imaging are being investigated. Anisotropic diffusion imaging enables white matter tracts to be demonstrated within the brain and spinal cord as a function of their direction because diffusion of water across axons is much more restricted than it is along them. This technique provides a unique method for localisation of lesions and displays obvious changes in disease in which diffusion becomes less restricted.

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References

  1. Ell P, Hocknell JML, Jarrett PH et al. (1985) A Tc99m labeled radiotracer for the investigation of cerebrovascular disease. Nuclear Med Commun 6: 437–441

    Google Scholar 

  2. Hahn EL (1950) Spin echoes. Phys Rev 80: 580–594

    Google Scholar 

  3. Carr HY, Purcell EM (1954) Effects of diffusion on free precession in nuclear magnetic resonance experiments. Phys Rev 94: 630–635

    Google Scholar 

  4. Woessner DE (1963) NMR spin echo self diffusion measurements on fluids endegoing restricted diffusion. J Phys Chem 67: 1365–1367

    Google Scholar 

  5. Stejskal EO (1965) Use of spin-echoes in a pulsed magnetic field gradient to study anisotropic, restricted diffusion and flow. J Chem Phys 43: 3597–3606

    Google Scholar 

  6. Tanner JE, Stejskal EO (1968) Restricted self-diffusion of protons in colloidal systems by the pulsed-gradient, spin-echo method. J Chem Phys 49: 1768–1777

    Google Scholar 

  7. Stejskal EO, Tanner JE (1964) Spin diffusion measurements: spin echoes in the presence of time dependent field gradient. J Chem Phys 42: 288–292

    Google Scholar 

  8. Tanner JE (1978) Transient diffusion in a system partitioned by permeable barriers. Application to NMR measurements with a pulsed field gradient. J Chem Phys 69: 1748–1754

    Google Scholar 

  9. Taylor DG, Bushell MC (1985) The spacial mapping of translational diffusion coefficients by the NMR imaging technique. Phys Med Biol 30: 345–349

    Google Scholar 

  10. Moran PR (1982) A flow zeugmatographic interleaved for NMR imaging in humans. Magn Reson Imaging 1: 197–203

    Google Scholar 

  11. Le Bihan D, Breton E, Lallemand D, Grenier P, Cabanis E, Laval-Jeantet M (1986) MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurological disorders. Radiology 80: 401–407

    Google Scholar 

  12. Le Bihan D, Breton E, Lallemand D, Ubin ML, Vignaud J, Laval-Jeantet M (1988) Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 168: 497–505

    Google Scholar 

  13. Ahn CB, Lee SY, Nalcioglu O, Cho ZH (1986) An improved nuclear magnetic resonance diffusion coefficient imaging method using an optimised pulse sequence. Med Phys 13: 789–793

    Google Scholar 

  14. Young IR, Bydder GM (1987) Demonstration of perfused flow in the brain using phase mapping. Meeting of the Society of Magnetic Resonance in Medicine, p 863 (abstract)

  15. Young IR, Coutts GA, Bryant DJ, Bydder GM (1989) Use of ultra long echo time imaging to assist in measuring the velocity of perfused flow in vivo. Magn Reson Med 10: 349–361

    Google Scholar 

  16. Bryant DJ, Payne JA, Fimin DN, Longmore DB (1984) Measurement of flow with NMR imaging using a gradient pulse and phase difference technique. J Comp Assist Tomogr 8: 588–593

    Google Scholar 

  17. Le Bihan D, Breton E, Syrota A (1985) In vivo magnetic resonance imaging of self diffusion. Meeting of the Society of Magnetic Resonance in Medicine, p 1238 (abstract)

  18. Mulkern RV, Spencer RGS (1988) Diffusion imaging with paired CPMG sequences. Magn Reson Med 6: 523–631

    Google Scholar 

  19. Merboldt KD, Bruhn H, Frahm J, Gyngell ML, Hanicke W, Deimling M (1989) MRI of diffusion in the human brain: new results using a modified CE-fast sequence. Magn Reson Med 9: 423–429

    Google Scholar 

  20. Le Bihan D, Turner R, Macfall JR (1989) Effects of intravoxel incoherent motions (IVIM) in steady state free precession (SSFP) imaging: application to molecular diffusion imaging. Magn Reson Med 10: 324–337

    Google Scholar 

  21. Turner R, Le Bihan D (1989) Echo planer diffusion and perfusion imaging at 2.0 T. Meeting of the Society of Magnetic Resonance, p 139 (abstract)

  22. Merboldt KD, Hanicke W, Frahm J (1985) Self diffusion NMR imaging using stimulated echoes. J Magn Reson 64: 479–486

    Google Scholar 

  23. Collins AG, Hall AS, Young IR, Bydder GM (1989) Problems with the observation of perfused flow using stimulated echos. Meeting of the Society of Magnetic Resonance in Medicine, p 910 (abstract)

  24. Goldstein DC, Kundel LH, Daube-Witherspoon ME, Thiabault LE, Goldstein EJ (1986) A silicon gel phantom suitable for multimodality imaging. Invest Radiol 22: 153–157

    Google Scholar 

  25. Blackband S, Mansfield P (1985) NMR imaging and diffusion in biopolymers. Meeting of the Society of Magnetic Resonance in Medicine, p 575 (abstract)

  26. Budinger F, Knittel BL, Bruner P, Harrinson C (1985) Tissue perfusion phantom for proton magnetic resonance flow studies. Meeting of the Society of Magnetic Resonance in Medicine, p 577 (abstract)

  27. Patz S, Hawkes RC (1986) The application of steady state free precession in the study of very slow flow. Magn Reson Med 3: 140–145

    Google Scholar 

  28. Le Bihan D, Delannoy J, Levin RL (1989) Temperature mapping with MR imaging of molecular diffusion: application to hyperthermia. Radiology 171: 853–857

    Google Scholar 

  29. Puffer DB, Lorenz CH, Pickens DR, Price RR (1989) Perfusion/diffusion separation: dependence on gradient factor combination. Meeting of the Society of Magnetic Resonance in Medicine, p 137 (abstract)

  30. Mosely ME (1989) Clinical usefulness of diffusion weighted MRI of extra axial tumours. Meeting of the Society of Magnetic Resonance in Medicine, p 100 (abstract)

  31. Berry I, Manelfe C, Demonet SF, Arruth P (1988) Intra voxel incoherent imaging (IVIM) of wallarian degeneration. AJNR 9: 1032 (abstract)

    Google Scholar 

  32. Young IR, Hall AS, Bryant DJ, Thomas DGT, Gill SS, Dubowitz LMS, Cowan F, Pennock JM, Bydder GM (1988) Assessment of brain perfusion with MR imaging. J Comput Assist Tomogr 12: 721–727

    Google Scholar 

  33. Fish DR, Brooks DJ, Young IR, Bydder GM (1988) Use of magnetic resonance imaging to identify changes in cerebral blood flow in epilepsia partialis continua. Magn Reson Med 8: 238–240

    Google Scholar 

  34. Puffer DB, Lorenz CH, Pickens DR, Price RR (1989) Evidence of coherent flow in magnetic resonance perfusion/diffusion imaging. Meeting of the Society of Magnetic Resonance in Medicine, p 906 (abstract)

  35. Moseley ME, Cohen Y, Mintovitch R, et al. (1990) Early detection of regional ischemia in cats: comparison of diffusion T2-weighted MRI and spectroscopy. Magn Reson Med 14: 330–346

    Google Scholar 

  36. Doran M, Hajnal JV, Van Bruggen N, King M, Young IR, Bydder GM (1990) Magnetic resonance imaging: use of directional diffusion weighted sequences to demonstrate normal and abnormal white matter tracts. J Comput Assist Tomogr (in press)

  37. Berry I, Manelfe C, Marc-Vergnes JP (1989) Correlation between intravoxel incoherent motion-(MRI) and cerebral blood flow (CBF) as measured by single photon emission tomography (SPECT). Meeting of the Society of Magnetic Resonance in Medicine, p 10 (abstract)

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Authors and Affiliations

  1. NMR Unit, Royal Postgraduate Medical School, London, England

    M. Doran & G. M. Bydder

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  1. M. Doran
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  2. G. M. Bydder
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Doran, M., Bydder, G.M. Magnetic resonance: perfusion and diffusion imaging. Neuroradiology 32, 392–398 (1990). https://doi.org/10.1007/BF00588472

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