, Volume 34, Issue 1, pp 73–76 | Cite as

Selective intra-arterial chemotherapy with BCNU in recurrent malignant gliomas

  • G. B. Bradac
  • R. Soffietti
  • A. Riva
  • G. Stura
  • S. Sales
  • D. Schiffer
Interventional Neuroradiology


Study of intra-arterial BCNU in 12 patients with recurrent glioblastoma multiforme and 5 patients with recurrent anaplastic astrocytoma already treated by surgery and radiotherapy indicates that the risk of BCNU toxicity can be reduced by the use of relatively low doses (160–180 mg/m2) of BCNU, the use of dextrose as solvent, selective injections of BCNU, and fast “bolus” injections of drug. No certain toxic effects of BCNU were observed in the 17 patients treated this way. Anaplastic astrocytomas, particularly in young patients, seem to respond relatively well to this treatment.

Key words

BCNU Chemotherapy Malignant gliomas 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Feindel W, Diksic M, Yamamoto L, Arnold D, Shoubridge E, Villemure JG (1989) Strategies for enhancing drug uptake in gliomas. In: Broggi G, Gerosa MA (eds) Cerebral gliomas. Elsevier, Amsterdam, pp 241–250Google Scholar
  2. 2.
    Levin VA, Kabra PM, Freeman-Dove MA (1978) Pharmacokinetics of intracarotid artery 14C-BCNU in the squirel monkey. J Neurosurg 48: 587Google Scholar
  3. 3.
    Theron J, Villemure JG, Worthington E, Tyler JL (1986) Superselective intracerebral chemotherapy of malignant tumours. Neuroradiology 28: 118Google Scholar
  4. 4.
    Chiras J, Dormont D, Fauchon F, Debussche C, Bories J (1988) Chimiotherapie intraarterielle des gliomes malins. J Neuroradiol 15: 31Google Scholar
  5. 5.
    Foo SH, Choi JS, Berenstein A, Wise A, Ransohoff J, Koslow M, George A, et al (1986) Supraophthalmic intracarotid infusion of BCNU for malignant glioma. Neurology 36: 1437Google Scholar
  6. 6.
    Greenberg HS, Ensminger WD, Chandler WF, Layton PB, Junck L, Knake J, Vine AK (1984) Intraarterial BCNU chemotherapy for treatment of malignant gliomas of the central nervous system. J Neurosurg 61: 423Google Scholar
  7. 7.
    Hochberg FH, Pruitt AA, Beck DO, Debrun G, Davis K (1985) The rational and methodology for intra-arterial chemotherapy with BCNU as treatment for glioblastoma. J Neurosurg 63: 876Google Scholar
  8. 8.
    Mahaley MS, Whaley RA, Blue M, Bertsch L (1986) Central neurotoxicity following intracarotid BCNU chemotherapy for malignant gliomas. J Neurooncol 3: 297Google Scholar
  9. 9.
    Clayman DA, Wolpert SM, Heros DO (1989) Superselective arterial BCNU infusion in the treatment of patients with malignant gliomas. AJNR 10: 767Google Scholar
  10. 10.
    MacDonald DR, Cascino TL, Schold SC, Cairncross JG (1990) Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol 8: 1277Google Scholar
  11. 11.
    Blacklock JB, Wright DC, Dedrick RL, Blasberg RG, Lutz RJ, Doppman JL, Oldfields EH (1986) Drug streaming during intraarterial chemotherapy. J Neurosurg 64: 284Google Scholar
  12. 12.
    Saris SC, Blasberg RG, Carson RE, De Vroom HL, Lutz R, Dedrick RL, Pettigrew K, et al (1991) Intravascular streaming during carotid artery infusions. J Neurosurg 74: 763Google Scholar
  13. 13.
    Bradac GB, Riva A, Soffietti R, Stura G, Schiffer D (1989) Chemioterapia arteriosa nei gliomi maligni. Esperienze preliminari. In: Pardatscher K (ed) Neuroradiologia 1989. Centauro, Udine, pp 207–210Google Scholar
  14. 14.
    Chiras J, Fauchon F, Poisson M, Debussche C, Chauveinc L, Pereon Y, Guerin RA, Bories J (1989) Traitment medical des gliomes malins inoperables. Chimiotherapie intraarterielle non hyperselective par HECNU suivie de radiotherapie conventionelle. Rev Neurol (Paris) 145: 829Google Scholar
  15. 15.
    Roosen N, Lins E, Kiwit JCW, Schirmer M, Bock WJ (1986) Intra-arterial chemotherapy with ACNU for the treatment of glioblastoma. Acta Radiol (Stockh) [Suppl] 369: 220–222Google Scholar
  16. 16.
    Bashir R, Hochberg FH, Linggood RM, Hottleman K (1988) Pre-irradiation internal carotid artery BCNU in treatment of glioblastoma multiforme. J Neurosurg 68: 917Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • G. B. Bradac
    • 1
  • R. Soffietti
    • 2
  • A. Riva
    • 1
  • G. Stura
    • 1
  • S. Sales
    • 1
  • D. Schiffer
    • 2
  1. 1.Department of Neuroradiology, Ospedale MolinetteUniversity of TurinTurinItaly
  2. 2.Department of Neurology, Ospedale MolinetteUniversity of TurinTurinItaly

Personalised recommendations