Neuroradiology

, Volume 35, Issue 8, pp 581–583 | Cite as

Gadolinium-enhanced MRI in cerebral Whipple's disease

  • E. Erdem
  • R. Carlier
  • A. Delvalle
  • R. Caquet
  • J. P. Etienne
  • D. Doyon
Diagnostic Neuroradiology

Abstract

Confusion developed in a 44-year-old man, who had diarrhoea and weight loss for three months. Jejunal biopsy showed infiltration by PAS-positive macrophages, indicating Whipple's disease. Cranial MRI disclosed multiple lesions mainly in the white matter and grey-white matter junction better demonstrated after gadolinium injection.

Key words

Whipple's disease Cerebral involvement Magnetic resonance imaging 

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References

  1. 1.
    Comer GM, Brandt LJ, Abissi CJ (1983) Whipple's disease: a review. Am J Gastroenterol 78:107–114Google Scholar
  2. 2.
    Fleming JL, Wiesner RH, Shorter RG (1988) Whipple's disease: clinical, biochemical, and histopathologic features and assessment of treatment in 29 patients. Mayo Clin Proc 63:539–551Google Scholar
  3. 3.
    Dobbins WO III (1988) Whipple's disease. Mayo Clin Proc 63: 623–624Google Scholar
  4. 4.
    Pallis CA, Lewis PD (1980) Neurology of gastrointestinal disease. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 39. North-Holland, Amsterdam, pp 449–468Google Scholar
  5. 5.
    Pollock S, Lewis PD, Kendall B (1981) Whipple's disease confined to the nervous system. J Neurol Neurosurg Psychiatry 44: 1104–1109Google Scholar
  6. 6.
    Adams M, Rhyner PA, Day J, DeArmond S, Smuckler EA (1987) Whipple's disease confined to the central nervous system. Ann Neurol 21:104–108Google Scholar
  7. 7.
    Brown AP, Lane JC, Murayama S, Vollmer DG (1990) Whipple's disease presenting with isolated neurological symptoms. J Neurosurg 73:623–627Google Scholar
  8. 8.
    Wroe SJ, Pires M, Harding B, Youl BD, Shorvon S (1991) Whipple's disease confined to the CNS presenting with multiple intracerebral mass lesions. J Neurol Neurosurg Psychiatry 54: 989–992Google Scholar
  9. 9.
    Ryser RJ, Locksley RM, Eng SC, Dobbins WO III, Schoenknecht FD, Rubin CE (1984) Reversal of dementia associated with Whipple's disease by trimethoprim-sulfamethoxazole, drugs that penetrate the blood brain barrier. Gastroenterology 86:745–752Google Scholar
  10. 10.
    Grossman RI, Davis KR, Halperin J (1981) Cranial computed tomography in Whipple's disease. J Comput Assist Tomogr 5: 246–248Google Scholar
  11. 11.
    Ludwig B, Bohl J, Haferkamp G (1981) Central nervous system involvement in Whipple's disease. Neuroradiology 21:289–293Google Scholar
  12. 12.
    Davion T, Rosat P, Sevestre H, Desablens B, Debussche C, Delamarre J, Capron JP (1990) MR imaging of CNS relapse of Whipple disease. J Comput Assist Tomogr 14:815–817Google Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • E. Erdem
    • 1
  • R. Carlier
    • 1
  • A. Delvalle
    • 1
  • R. Caquet
    • 2
  • J. P. Etienne
    • 3
  • D. Doyon
    • 1
  1. 1.Department of NeuroradiologyHôpital de BicêtreLe Kremlin-BicêtreFrance
  2. 2.Department of Internal MedicineHôpital de BicêtreLe Kremlin-BicêtreFrance
  3. 3.Department of GastroenterologyHôpital de BicêtreLe Kremlin-BicêtreFrance

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