Summary
Using xenon-enhanced computed tomography for the study of cerebral blood flow, simultaneous measurements of end-tidal and arterial blood xenon concentrations using the blood collection method were performed to investigate the validity of substituting the end-tidal for the arterial blood xenon concentration. Simultaneous measurement by both methods was performed 68 times in 27 patients. There was no statistical correlation between the arterial blood accumulation rate constant obtained by arterial blood and end-tidal samples, nor between the arterial blood saturation value obtained by the two methods, even when correction was made for age. In brain tissue, all parameters calculated using the end-tidal concentration were lower than those using arterial blood. We therefore suggest that cerebral blood flow values calculated using end-tidal xenon concentration are useful only for qualitative cerebral blood flow mapping, and not applicable to absolute values of cerebral blood flow.
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References
Yonas H, Wolfson SK Jr, Gur D, Latchaw RE, Good WF, Leanza R, Jackson DL, Jannetta PJ, Reinmuth OM (1984) Clinical experience with the use of xenon-enhanced CT blood flow mapping in cerebral vascular disease. Stroke 15:443–450
Yonas H, Good WF, Gur D, Wolfson SK Jr, Latchaw RE, Good BC, Leanza R, Miller SL (1984) Mapping cerebral blood flow by xenon-enhanced computed tomography: clinical experience. Radiology 152:435–442
Meyer JS, Hayman LA, Yamamoto M, Sakai F, Nakajima S (1980) Local cerebral blood flow measured by CT after stable xenon inhalation. AJR 135:239–251
Gur D, Wolfson SK, Yonas H, Good WF, Shabason L, Latchaw RE, Miller DM, Cook EE (1982) Progress in cerebrovascular disease: local cerebral blood flow by xenon enhanced CT. Stroke 13:750–758
Segawa H, Wakai S, Tamura A, Yoshimasu N, Nakamura O, Ohta M (1983) Computed tomographic measurement of local cerebral blood flow by xenon enhancement. Stroke 14:356–362
Suga S, Toya S, Kawase T, Koyama H, Shiga H (1986) Appropriate xenon-inhalation speed in xenon-enhanced CT using the endtidal gas-sampling method. Progr CT 8:397–403
Touho H, Karasawa J, Shishido H, Yamada K, Yamazaki Y, Asai M, Kawabata K, Kobayashi K, Kitamura T, Kagawa M (1989) Stable xenon CT-CBF study with measurement of end-tidal xenon concentration: correlation by arterial concentration of xenon. Brain Nerve 41:603–609
Keltz F, Hilal SK, Hartwell P, Joseph PM (1978) Computed tomographic measurement of the xenon brain-blood partition coefficient and implication for regional cerebral blood flow: a preliminary report. Radiology 127:385–392
Stock MC (1988) Noninvasive carbon dioxide monitoring. Crit Care Clin 4:511–526
Nunn JF, Hill DW (1960) Respiratory dead space and arterial to end-tidal CO2 tension difference in anesthetized man. J Appl Physiol 15:383–389
Raemer DB, Francis D, Philip JH, Gabel RA (1983) Variation in PCO2 between arterial blood and peak expired gas during anesthesia. Anesth Analg 62:1065–1069
Yamanaka MK, Sue DY (1987) Comparison of arterial-end-tidal PCO2 difference and dead space/tidal volume ratio in respiratory failure. Chest 92:832–835
Murray IP, Modell JH (1983) Early detection of endotracheal tube accidents by monitoring carbon dioxide concentration in respiratory gas. Anesthesiology 59:344–346
Cullen SC, Gross EG (1951) The anesthetic properties of xenon in animals and human beings, with additional observations on krypton. Science 113:580–582
Morris LE, Knott JR, Pittinger CB (1955) Electroencephalographic and blood gas observations in human surgical patients during xenon anesthesia. Anesthesiology 16:312–319
Winkler S, Turski P, Holden J, Koeppe R, Rusy B, Garber E (1985) Xenon effects on CNS control of respiratory rate and tidal volume — the danger of apnea. In: Hartmann A, Hoyer S (eds) Cerebral blood flow and metabolism measurement. Springer, Berlin Heidelberg New York, pp 56–360
Winkler S, Turski P (1985) Potential hazards of xenon inhalation. AJNR 6:974–975
Meyer JS, Shinohara T, Imai A, Kobari M, Sakai F, Hata T, Oravez WT, Timpe GM, Deville T, Solomon E (1988) Imaging local cerebral blood flow by xenon-enhanced computed tomography: technical optimization procedures. Neuroradiology 30:283–292
Segawa H, Yoshimasu N, Nakamura O, Aritake K, Wakai S, Takakura K, Kimura K, Ueda Y, Tamura A, Sano K (1982) Computed tomographic measurement of regional cerebral blood flow by xenon enhancement. Brain Nerve 34:291–297
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Shimoda, M., Oda, S., Sato, O. et al. Discrepancy of xenon concentrations between end-tidal and blood collection methods in xenon-enhanced computed tomographic measurement of cerebral blood flow. Neuroradiology 35, 66–68 (1992). https://doi.org/10.1007/BF00588282
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DOI: https://doi.org/10.1007/BF00588282