Summary
Temporal lobe epilepsy is diagnosed by clinical symptoms and signs and by localization of an epileptogenic focus. A brain SPECT study of two patients with temporal lobe epilepsy, using99mTc-HMPAO, was used to demonstrate a perfusion abnormality in the temporal lobe, while brain CT and MRI were non-contributory. The electroencephalogram, though abnormal, did not localize the diseased area. The potential role of the SPECT study in diagnosis and localization of temporal lobe epilepsy is discussed.
Similar content being viewed by others
References
Andersen AR, Gram L, Kjaer L, Fuglsang-Frederiksen A, Herning M, Lassen NA, Dam M (1988) SPECT in partial epilepsy: Identifying side of the focus. Acta Neurol Scand [Suppl] 117: 90–95
Latack JT, Abou-Khalil BW, Siegel GJ, Sackellares JC, Gabrielsen TO, Aisen AM (1986) Patients with partial seizures: evaluation by MR, CT and PET imaging. Radiology 159: 159–163
Sharp PF, Smith FW, Gemmel HG, Lyall D, Evans NTS, Gvozdanovic D, Davidson J, Tyrrell DA, Pickett RD, Neirinckx RD (1986) Technetium 99m HM-PAO stereoisomers as potential agents for imaging regional cerebral blood flow: human volunteer studies. J Nucl Med 27: 171–177
Ojemann GA (1987) Surgical therapy for medically intractable epilepsy. J Neurosurg 66: 489–499
Oakley J, Ojemann GA, Ojemann LM, Cromwell L (1979) Identifying epileptic foci on contrast-enhanced computerized tomographic scans. Arch Neurol 36: 669–671
McGahan JP, Dublin AB, Hill RP (1979) The evaluation of seizure disorders by computerized tomography. J Neurosurg 50: 328–332
Bolender NF, Wyler AR (1982) CT measurements of mesial temporal lobe herniations in epileptics. Epilepsia 23: 409–416
Wyler AR, Bolendr NF (1983) Preoperative CT diagnosis of mesial temporal sclerosis for surgical treatment of epilepsy. Ann Neurol 13: 59–64
Biersack HJ, Reichmann K, Winkler C, Stefan H, Bulau P, Kuhnen K, Perin H, Tyrrell DA, Neirinckx RD, Gruner KR (1985)99mTc-labelled Hexamethylpropylenamine oxime photon emission scans in epilepsy. Lancet: 1436–1437
Stone JL, Hughes JR, Barr A, Tan W, Russell E, Crowell RM (1986) Neuroradiological and electroencephalographic features in a case of temporal lobe status epilepticus. Neurosurgery 18: 212–216
Laster DW, Penry JK, Moody DM, Ball MR, Witcofski RL, Riela AR (1985) Chronic seizure disorders: Contribution of MR imaging when CT is normal. AJNR 6: 177–180
Engel J, Rausch R, Lieb JP, Kuhl DE, Crandall PH (1981) Correlation of criteria used for localizing epileptic foci in patients considered for surgical therapy of epilepsy. Ann Neurol 9: 215–224
Lesser RP, Modic MT, Weinstein MA, Duchesneau PM, Luders H, Dinner DS, Moris HH, Estes M, Chou SM, Hahn JF (1986) Magnetic resonance imaging (1.5 tesla) in patients with intractable focal seizures. Arch Neurol 43: 367–371
Theodore WH, Newmark ME, Sato S, Brooks R, Patronas N, De La Paz R, Dichiro G, Kessler RM, Margolin R, Manning RG, Channing M, Porter RJ (1983) [18F] Fluorodeoxyglucose positron emission tomography in refractory complex partial seizures. Ann Neurol 14: 429–437
Smith FW, Gemmell HG, Sharp PF (1987) The use of99mTc-HMPAO for the diagnosis of dementia. Nucl Med Commun 8: 523–533
Cohen D, Krausz Y, Lossos A, Ben-David E, Atlan H (1989) Brain SPECT imaging with99mTc-HMPAO in Creutzfeld-Jakob disease. Clin Nucl Med 14: 808–810
Stefan H, Kuhnen C, Biersack HJ, Riechmann K (1987) Initial experience with99mTc-hexamethyl-propylene amine oxime (HMPAO) single photon emissin computer tomography (SPECT) in patients with focal epilepsy. Epilepsy Res 1: 134–138
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Krausz, Y., Cohen, D., Konstantini, S. et al. Brain SPECT imaging in temporal lobe epilepsy. Neuroradiology 33, 274–276 (1991). https://doi.org/10.1007/BF00588236
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00588236