Summary
Two children with congenital rubella virus and six with cytomegalovirus (CMV) infections, were examined by magnetic resonance (MR) and CT. Cranial MR imaging (MRI) with T2-weighted spin-echo (SE) and inversion recovery (IR) sequences demonstrated the following: periventricular hyperintensity (4), subcortical hyperintensity (5), delayed myelination (4), oligo/pachygyria (2), cerebellar hypoplasia (2). This study showed that the more-disabled children had more marked abnormal MRI findings. MRI was more effective in the detection of parenchymal lesion than was CT, although intraventricular calcification was better visualized with CT.
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Desmond MM, Wilson GS, Melnick JL, Singer DB, Zion TE, Rudolph AJ, Pineda RG, Ziai M-H, Blattner RJ (1967) Congenital rubella encephalitis. course and early sequelae. J Pediatr 71: 311–331
Preece PM, Pearl KN, Peckham CS (1984) Congenital cytomegalovirus infection. Arch Dis Child 59: 1120–1126
Cooper LZ, Krugman S (1967) Clinical manifestations of postnatal and congenital rubella. Arch Ophthalmol 77: 434–439
Pass RF, Stagno S, Myers GJ, Alford CA (1980) Outcome of symptomatic congenital cytomegalovirus infection; results of long-term longitudinal follow-up. Pediatrics 66: 758–762
Saigal S, Lunyk O, Larke RPB, Chernesky MA (1982) The outcome in children with congenital cytomegalovirus infection. a longitudinal follow-up study. Am J Dis Child 136: 896–901
Kumar ML, George A, Nankervis GA, Jacobs IB, Ernhart CB, Glasson CE, McMillan PM, Gold E (1984) Congenital and postnatally acquired cytomegalovirus infections: long-term follow-up. J Pediatr 104: 674–679
Bignami A, Appicciutoli L (1964) Micropolygyria and cerebral calcification in cytomegalic inclusion disease. Acta Neuropathol (Berl) 4: 127–137
Rorke LB, Spiro AJ (1967) Cerebral lesions in congenital rubella syndrome. J Pediatr 70: 243–255
Bray PF, Bale JF, Anderson RE, Kern ER (1981) Progressive neurological disease associated with chronic cytomegalovirus infection. Ann Neurol 9: 499–502
Friede RL (1989) Infections of fetus. In: Developmental neuropathology. Springer, Berlin Heidelberg New York, pp 156–168
Bale JF, Bray PF, Bell WE (1985) Neuroradiographic abnormalities in congenital cytomegalovirus infection. Pediatr Neurol 1: 42–47
Boesch Ch, Issakainen J, Kewitz G, Kikinis R, Martin E, Boltshauser E (1989) Magnetic resonance imaging of the brain in congenital cytomegalovirus infection. Pediatr Radiol 19:91–93
Sugita K, Iai M, Nakajima H, Ohta R (1988) Consistency and changes in the development of extremely low birthweight infants. Brain Dev 10: 231–235
Sugita K, Takeuchi A, Iai M, Tanabe Y (1989) Neurologic sequenlae and MRI in low-birth weight patients. Pediatr Neurol 5: 365–369
Young RSK, Osbakken MD, Alger PM, Ramer JC, Weidner WA, Daigh JD (1985) Magnetic resonance imaging in leukodystrophies of childhood. Pediatr Neurol 1: 15–19
Bradley WG (1987) Pathophysiologic correlates of signal alterations. In: Brand-Zawadzki M, Norman D (eds) Magnetic resonance imaging of the central nervous system. Raven Press, New York, pp 23–42
McArdle CB, Richardson CJ, Nicholas DA, Mirfakhraee M, Hayden CK, Amparo EG (1987) Developmental features of the neonatal brain: MR imaging. Part I. Gray-white matter differentiation and myelination. Radiology 162: 223–229
McArdle CB, Richardson CJ, Hayden CK, Nicholas DA, Amparo EG (1987) Abnormalities of the neonatal brain: MR imaging. Part II. Hypoxic-ischemic brain injury. Radiology 163: 395–403
Ford LM, Kim Han B, Steichen J, Babcock D, Fogelson H (1989) Very low-birth-weight, preterm infants with or without intracranial hemorrhage. Clin Pediatr 28: 302–310
Ishikawa A, Murayama T, Sakuma N, Takase A, Shishido T, Nagamatsu K, Nanbu H (1982) Computed cranial tomography in congenital rubella syndrome. Arch Neurol 39: 420–421
Atlas SW, Grossman RI, Hackney DB, Gomori JM, Campagna N, Goldberg HI, Bilaniuk LT, Zimmerman RA (1988) Calcified intracranial lesions: detection with gradient-echo-acquisition rapid MR imaging. AJNR 9: 253–259
Diezel PB (1954) Mikrogyrie infolge cerebraler Speicheldrüsenvirusinfektion im Rahmen einer generelisierten Cytomegalie bei einem Säugling. Zugleich ein Beitrag zur Theorie der Windungsbildung. Virchows Arch [A] 325: 109–130
Friede RL, Mikolasek J (1978) Postencephalitic porencephaly, hydroanencephaly or polymicrogyria. a review. Acta Neuropathol (Berl) 43: 161–168
Marques Dias MJ, Harmant-van Rijkevorsel G, Landrieu P, Lyon G (1983) Prenatal cytomegalovirus disease and cerebral microgyria: evidence for perfusion failure, not disturbance of histogenesis as the major cause of cytomegalovirus encephalopathy. Neuropediatrics 15: 18–24
Griffith JF (1977) Nonbacterial infection of the fetus and newborn. Clin Perinatol 4: 117–130
Rorke LB (1973) Nervous system lesions in the congenital rubella syndrome. Arch Otolaryngol Head Neck Surg 98: 249–251
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Sugita, K., Ando, M., Makino, M. et al. Magnetic resonance imaging of the brain in congenital rubella virus and cytomegalovirus infections. Neuroradiology 33, 239–242 (1991). https://doi.org/10.1007/BF00588225
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DOI: https://doi.org/10.1007/BF00588225