Skip to main content

Advertisement

Log in

Magnetic resonance imaging of the brain in congenital rubella virus and cytomegalovirus infections

  • Originals
  • Published:
Neuroradiology Aims and scope Submit manuscript

Summary

Two children with congenital rubella virus and six with cytomegalovirus (CMV) infections, were examined by magnetic resonance (MR) and CT. Cranial MR imaging (MRI) with T2-weighted spin-echo (SE) and inversion recovery (IR) sequences demonstrated the following: periventricular hyperintensity (4), subcortical hyperintensity (5), delayed myelination (4), oligo/pachygyria (2), cerebellar hypoplasia (2). This study showed that the more-disabled children had more marked abnormal MRI findings. MRI was more effective in the detection of parenchymal lesion than was CT, although intraventricular calcification was better visualized with CT.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Desmond MM, Wilson GS, Melnick JL, Singer DB, Zion TE, Rudolph AJ, Pineda RG, Ziai M-H, Blattner RJ (1967) Congenital rubella encephalitis. course and early sequelae. J Pediatr 71: 311–331

    Google Scholar 

  2. Preece PM, Pearl KN, Peckham CS (1984) Congenital cytomegalovirus infection. Arch Dis Child 59: 1120–1126

    Google Scholar 

  3. Cooper LZ, Krugman S (1967) Clinical manifestations of postnatal and congenital rubella. Arch Ophthalmol 77: 434–439

    Google Scholar 

  4. Pass RF, Stagno S, Myers GJ, Alford CA (1980) Outcome of symptomatic congenital cytomegalovirus infection; results of long-term longitudinal follow-up. Pediatrics 66: 758–762

    Google Scholar 

  5. Saigal S, Lunyk O, Larke RPB, Chernesky MA (1982) The outcome in children with congenital cytomegalovirus infection. a longitudinal follow-up study. Am J Dis Child 136: 896–901

    Google Scholar 

  6. Kumar ML, George A, Nankervis GA, Jacobs IB, Ernhart CB, Glasson CE, McMillan PM, Gold E (1984) Congenital and postnatally acquired cytomegalovirus infections: long-term follow-up. J Pediatr 104: 674–679

    Google Scholar 

  7. Bignami A, Appicciutoli L (1964) Micropolygyria and cerebral calcification in cytomegalic inclusion disease. Acta Neuropathol (Berl) 4: 127–137

    Google Scholar 

  8. Rorke LB, Spiro AJ (1967) Cerebral lesions in congenital rubella syndrome. J Pediatr 70: 243–255

    Google Scholar 

  9. Bray PF, Bale JF, Anderson RE, Kern ER (1981) Progressive neurological disease associated with chronic cytomegalovirus infection. Ann Neurol 9: 499–502

    Google Scholar 

  10. Friede RL (1989) Infections of fetus. In: Developmental neuropathology. Springer, Berlin Heidelberg New York, pp 156–168

    Google Scholar 

  11. Bale JF, Bray PF, Bell WE (1985) Neuroradiographic abnormalities in congenital cytomegalovirus infection. Pediatr Neurol 1: 42–47

    Google Scholar 

  12. Boesch Ch, Issakainen J, Kewitz G, Kikinis R, Martin E, Boltshauser E (1989) Magnetic resonance imaging of the brain in congenital cytomegalovirus infection. Pediatr Radiol 19:91–93

    Google Scholar 

  13. Sugita K, Iai M, Nakajima H, Ohta R (1988) Consistency and changes in the development of extremely low birthweight infants. Brain Dev 10: 231–235

    Google Scholar 

  14. Sugita K, Takeuchi A, Iai M, Tanabe Y (1989) Neurologic sequenlae and MRI in low-birth weight patients. Pediatr Neurol 5: 365–369

    Google Scholar 

  15. Young RSK, Osbakken MD, Alger PM, Ramer JC, Weidner WA, Daigh JD (1985) Magnetic resonance imaging in leukodystrophies of childhood. Pediatr Neurol 1: 15–19

    Google Scholar 

  16. Bradley WG (1987) Pathophysiologic correlates of signal alterations. In: Brand-Zawadzki M, Norman D (eds) Magnetic resonance imaging of the central nervous system. Raven Press, New York, pp 23–42

    Google Scholar 

  17. McArdle CB, Richardson CJ, Nicholas DA, Mirfakhraee M, Hayden CK, Amparo EG (1987) Developmental features of the neonatal brain: MR imaging. Part I. Gray-white matter differentiation and myelination. Radiology 162: 223–229

    Google Scholar 

  18. McArdle CB, Richardson CJ, Hayden CK, Nicholas DA, Amparo EG (1987) Abnormalities of the neonatal brain: MR imaging. Part II. Hypoxic-ischemic brain injury. Radiology 163: 395–403

    Google Scholar 

  19. Ford LM, Kim Han B, Steichen J, Babcock D, Fogelson H (1989) Very low-birth-weight, preterm infants with or without intracranial hemorrhage. Clin Pediatr 28: 302–310

    Google Scholar 

  20. Ishikawa A, Murayama T, Sakuma N, Takase A, Shishido T, Nagamatsu K, Nanbu H (1982) Computed cranial tomography in congenital rubella syndrome. Arch Neurol 39: 420–421

    Google Scholar 

  21. Atlas SW, Grossman RI, Hackney DB, Gomori JM, Campagna N, Goldberg HI, Bilaniuk LT, Zimmerman RA (1988) Calcified intracranial lesions: detection with gradient-echo-acquisition rapid MR imaging. AJNR 9: 253–259

    Google Scholar 

  22. Diezel PB (1954) Mikrogyrie infolge cerebraler Speicheldrüsenvirusinfektion im Rahmen einer generelisierten Cytomegalie bei einem Säugling. Zugleich ein Beitrag zur Theorie der Windungsbildung. Virchows Arch [A] 325: 109–130

    Google Scholar 

  23. Friede RL, Mikolasek J (1978) Postencephalitic porencephaly, hydroanencephaly or polymicrogyria. a review. Acta Neuropathol (Berl) 43: 161–168

    Google Scholar 

  24. Marques Dias MJ, Harmant-van Rijkevorsel G, Landrieu P, Lyon G (1983) Prenatal cytomegalovirus disease and cerebral microgyria: evidence for perfusion failure, not disturbance of histogenesis as the major cause of cytomegalovirus encephalopathy. Neuropediatrics 15: 18–24

    Google Scholar 

  25. Griffith JF (1977) Nonbacterial infection of the fetus and newborn. Clin Perinatol 4: 117–130

    Google Scholar 

  26. Rorke LB (1973) Nervous system lesions in the congenital rubella syndrome. Arch Otolaryngol Head Neck Surg 98: 249–251

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sugita, K., Ando, M., Makino, M. et al. Magnetic resonance imaging of the brain in congenital rubella virus and cytomegalovirus infections. Neuroradiology 33, 239–242 (1991). https://doi.org/10.1007/BF00588225

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00588225

Key words

Navigation