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Pflügers Archiv

, Volume 320, Issue 4, pp 359–372 | Cite as

The cochlear potentials

II. The nature of the cochlear endolymphatic resting potential
  • W. Kuijpers
  • S. L. Bonting
Article

Summary

The effect, on the endocochlear resting potential (ERP) of anoxemia, cyanide, pH changes and changes of the electrolyte composition of the perilymph was studied.

The ERP appears to be composed of two components: a negative potentialE-mainly determined by the K+ gradient between endolymph and perilymph or plasma and a positive potentialE+ due to an ouabain- and anoxia-sensitive electrogenic K+ pump represented by the Na+-K+-ATPase system of the stria vascularis.

Maintenance of the ionic concentrations of the endolymph appears to require in addition active transport of Na+ and Cl out of the endolymph.

Key-Words

Endocochlear Resting Potential Stria. Vascularis Electrogenic K+-Pump K+-Diffusion Potential Guinea Pig 

Schlüsselwörter

Endocochleares Potential Stria vascularis Elektrogene K+-Pumpe K+-Diffusionspotential Meerschweinchen 

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Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • W. Kuijpers
    • 1
    • 2
  • S. L. Bonting
    • 1
    • 2
  1. 1.Department of OtolaryngologyUniversity of NijmegenNijmegenThe Netherlands
  2. 2.Department of BiochemistryUniversity of NijmegenNijmegen

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