, Volume 34, Issue 4, pp 313–315 | Cite as

Cerebral MRI in two brothers with mucopolysaccharidosis type I and different clinical phenotypes

  • O. Gabrielli
  • U. Salvolini
  • M. Maricotti
  • M. G. Mariani
  • G. V. Coppa
  • P. L. Giorgi
Diagnostic Neuroradiology


We describe a cerebral MRI study of two brothers with mucopolysaccharidosis type I. They are of similar physical appearance, but the younger is severely mentally retarded while the elder is of normal intelligence. MRI shows characteristic abnormalities in the CNS, but it is not yet possible to establish a correlation between them and the mental retardation.

Key words

Cerebral magnetic resonance imaging Mental retardation Mucopolysaccharidoses Alpha-L-iduronidase deficiency 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • O. Gabrielli
    • 1
  • U. Salvolini
    • 2
  • M. Maricotti
    • 3
  • M. G. Mariani
    • 1
  • G. V. Coppa
    • 1
  • P. L. Giorgi
    • 1
  1. 1.Department of PaediatricsUniversity of AnconaAnconaItaly
  2. 2.Department of NeuroradiologyUniversity of AnconaAnconaItaly
  3. 3.Department of NeurologyUniversity of AnconaAnconaItaly

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