Abstract
The concentration of extracellular potassium, [K+]e, was measured in parietal cortex and basal ganglia of rats during and after ten minutes of complete cerebral ischemia. The post-ischemic normalization of [K+]e was considerably delayed in parietal cortex compared to basal ganglia, but in both regions, [K+]e reached its normal concentration within 4 min of the end of the ischemia. Also, in both regions blood flow was elevated at the time of maximal [K+]3 decrease. Our findings suggest that the normalization of [K+]e and cerebrovascular resistance after ischemia are related by positive feed-back, possibly via the stimulation of Na+−K+-ATPase.
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Hansen, A.J., Gjedde, A. & Siemkowicz, E. Extracellular potassium and blood flow in the post-ischemic rat brain. Pflugers Arch. 389, 1–7 (1980). https://doi.org/10.1007/BF00587921
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DOI: https://doi.org/10.1007/BF00587921