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The influence of antibodies against bradykinin on isotonic saline diuresis in the rat

Evidence for kinin involvement in renal function

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Summary

The urinary excretion of water, sodium and potassium by salineloaded rats treated with antibradykinin serum was studied. Control animals received normal rabbit serum. Blockade of the kallikrein system by bradykinin-binding antibodies resulted in a decreased natriuretic and diuretic response to expansion of the extracellular space. The fractional excretion of sodium and water was lower in antibradykinin-treated rats. Antibradykinin serum did not affect the clearances of PAH or inulin, nor did it influence potassium excretion. The reduced ability of antibradykinin-treated rats to excrete a saline load suggests that a normally functioning kallikrein system may be a prerequisite for the occurrence of saline diuresis after extracellular fluid volume expansion.

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Authors and Affiliations

  1. Institut de Pharmacologie de l'Université de Lausanne, 21, Rue du Bugnon, CH-1011, Lausanne, Switzerland

    Marcos Marin Grez

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  1. Marcos Marin Grez
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Supported by Fonds National Suisse de la Recherche Scientifique, Grant No. 3.7420.72.

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Grez, M.M. The influence of antibodies against bradykinin on isotonic saline diuresis in the rat. Pflugers Arch. 350, 231–239 (1974). https://doi.org/10.1007/BF00587802

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  • DOI: https://doi.org/10.1007/BF00587802

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