Summary
All acidic non-steroidal anti-inflammatory drugs suppress the activity of microsomal cyclo-oxygenase of arachidonic acid; therefore, these drugs are equipotent inhibitors of prostaglandin and thromboxane generation. A non-acidic anti-inflammatory agent, 1′- (isopropyl-2-indolyl)-3-pyridyl-3-ketone (L 8027), selectively inhibits biosynthesis of thromboxane A2 in blood platelets and in lungs.
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Gryglewski, R.J. Prostaglandin and thromboxane biosynthesis inhibitors. Naunyn-Schmiedeberg's Arch. Pharmacol. 297 (Suppl 1), S85–S88 (1977). https://doi.org/10.1007/BF00587789
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DOI: https://doi.org/10.1007/BF00587789