Summary
The enzymatic fragmentation of TRH (pyroGlu-His-Pro-NH2) by serum, hypothalamic and hypophyseal tissue was investigated. As primary cleavage product only His-Pro-NH2 was detected when TRH was incubated with serum while with the tissue preparations the formation of His-Pro-NH2, deamido-TRH and prolineamide could be detected as enzymatically formed primary fragments.
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References
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Bauer, K. Degradation of hypothalamic hormones. Naunyn-Schmiedeberg's Arch. Pharmacol. 297 (Suppl 1), S55–S56 (1977). https://doi.org/10.1007/BF00587778
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DOI: https://doi.org/10.1007/BF00587778